CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM731
Family Name Disintegrin and metalloproteinase domain-containing protein 17 inhibitor (5R)-5-[(5-fluoro-3-oxo-1H-isoindol-2-yl)methyl]-5-[4-(6-oxo-1H-pyridin-3-yl)phenyl]imidazolidine-2,4-dione family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00314778 Functional Category Bioactive
Superfamily Disintegrin and Beta-lactamase Binder Superfamily
Class Class 1635

Cousin Family NamesSeedsMembers
Sodium channel Ligand hydantoin derivative Phenytoin Family 2 25
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Mephenytoin... 5 51
DNA Binder Procarbazine Family 8 358
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Disintegrin and metalloproteinase domain-containing protein 17... 3 2
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Survival motor neuron protein inhibitor CHEMBL1323700 family 1 4
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Melanin-concentrating hormone receptor 1 ligand (3S)-3-[[5-(4-... 15 16
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075C6K ... 3 22
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Melanin-concentrating hormone receptor 1 ligand N-methyl-4-(4-... 1 0
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Prothrombin inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethyl... 8 1
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
Cannabinoid receptor 1 and Fatty-acid amide hydrolase 1 ligand... 2 3
Prolyl endopeptidase inhibitor 3eq9 family 1 0
Cannabinoid receptor 1 ligand 3-butyl-5,5-bis(4-iodophenyl)-2-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00314780 CHEMBL1087294 Bioactive AGN-PC-07ZAGE
CFAMM00314779 CHEMBL1222942 Bioactive SureCN7899568
CFAMM00314778 CHEMBL1222941 Bioactive (5R)-5-[(5-fluoro-3-oxo-1H-isoindol-2-yl)methyl]-5-[4-(6-oxo-1H-pyridin-3-yl)phenyl]imidazolidine-2,4-dione
CFAMM00314781 CHEMBL1222801 Bioactive SureCN7899500

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27264 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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