CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7316
Family Name Inhibitor of nuclear factor kappa-B kinase subunit beta inhibitor AGN-PC-09QK9K family
No. of Seeds 34 No. of Other Members 4
Family Centroid CFAMM00379046 Functional Category Bioactive
Superfamily Binder Superfamily 10
Class Class 1053

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
PHA848125 family 13 138
Smoothened homolog Inhibitor LY2940680 Family 3 18
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Smoothened homolog inhibitor SureCN1091571 family 2 2
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 5 19
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
B1 bradykinin receptor ligand 6-(8-fluoro-4-methyl-1-oxophthal... 3 0
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Coagulation factor X inhibitor 2-(6-chloronaphthalen-2-yl)-5-m... 2 0
Coagulation factor X inhibitor SureCN8169809 family 12 18
Coagulation factor X inhibitor SureCN8165148 family 4 0
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Coagulation factor X inhibitor AGN-PC-0749DA family 3 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Coagulation factor X inhibitor AGN-PC-02WFR7 family 7 13
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
B1 bradykinin receptor ligand SureCN6045889 family 4 9
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Cannabinoid receptor 1 ligand AGN-PC-07RA6C family 21 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00379046 CHEMBL1669555 Bioactive AGN-PC-09QK9K
CFAMM00379059 CHEMBL1669599 Bioactive AGN-PC-09QK9M
CFAMM00379072 CHEMBL1669569 Bioactive AGN-PC-09QJ33
CFAMM00379039 CHEMBL1669570 Bioactive AGN-PC-09QJE6
CFAMM00379045 CHEMBL1669554 Bioactive AGN-PC-09QGRB
CFAMM00379058 CHEMBL1669598 Bioactive AGN-PC-09QLN9
CFAMM00379071 CHEMBL1669565 Bioactive AGN-PC-09QLZC
CFAMM00379038 CHEMBL601079 Bioactive SureCN6198177
CFAMM00379051 CHEMBL1669608 Bioactive AGN-PC-09QLZE
CFAMM00379064 CHEMBL1669601 Bioactive AGN-PC-09QMSO
CFAMM00379044 CHEMBL1669557 Bioactive AGN-PC-09QGRC
CFAMM00379057 CHEMBL1669595 Bioactive AGN-PC-09QLZD
CFAMM00379070 CHEMBL1669566 Bioactive AGN-PC-09QL5D
CFAMM00379050 CHEMBL1669605 Bioactive AGN-PC-09QIJY
CFAMM00379043 CHEMBL1669556 Bioactive AGN-PC-09QMSM
CFAMM00379056 CHEMBL1669594 Bioactive AGN-PC-09QIJW
CFAMM00379069 CHEMBL1669567 Bioactive AGN-PC-09QIJV
CFAMM00379049 CHEMBL1669604 Bioactive AGN-PC-09QGRG
CFAMM00379062 CHEMBL1669600 Bioactive AGN-PC-09QIJX
CFAMM00379042 CHEMBL1669573 Bioactive AGN-PC-09QGRD
CFAMM00379055 CHEMBL1669597 Bioactive AGN-PC-09QK9L
CFAMM00379068 CHEMBL1669562 Bioactive AGN-PC-09QL5C
CFAMM00379048 CHEMBL1669607 Bioactive AGN-PC-09QK9N
CFAMM00379061 CHEMBL1669603 Bioactive AGN-PC-09QMSP
CFAMM00379074 CHEMBL592893 Bioactive AGN-PC-03NFZM
CFAMM00379041 CHEMBL1669572 Bioactive AGN-PC-09QHNI
CFAMM00379054 CHEMBL1669596 Bioactive AGN-PC-09QGRF
CFAMM00379067 CHEMBL1669563 Bioactive AGN-PC-09QLZA
CFAMM00379073 CHEMBL1669568 Bioactive AGN-PC-09QHNH
CFAMM00379047 CHEMBL1669552 Bioactive AGN-PC-09QK9J
CFAMM00379060 CHEMBL1669602 Bioactive AGN-PC-09QHNJ
CFAMM00379040 CHEMBL1669571 Bioactive AGN-PC-09QMSN
CFAMM00379053 CHEMBL1669593 Bioactive AGN-PC-09QGRE
CFAMM00379066 CHEMBL610730 Bioactive AGN-PC-03NG0M

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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