CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7321
Family Name Trace amine-associated receptor 1 ligand EPPTB family
No. of Seeds 4 No. of Other Members 9
Family Centroid CFAMM00379108 Functional Category Bioactive with Natural Product
Superfamily Cholesteryl ester transfer protein and Prelamin-A/C Binder Superfamily
Class Class 1685

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Nemonapride Family 70 283
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
D(2) dopamine receptor Ligand Aplindore Fumarate Family 2 30
Cinitapride family 4 22
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Substance-K receptor Ligand MEN-14933 Family 13 154
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 2
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Microsomal triglyceride transfer protein large subunit inhibit... 4 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 35
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Delta-type opioid receptor and Kappa-type opioid receptor liga... 15 6
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 2 4
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 4 1
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Motilin receptor ligand SureCN14564469 family 1 6
Galanin receptor type 3 and Alpha-1A adrenergic receptor ligan... 2 16
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 2 6
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 4 4
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-(3-methoxy-2-me... 2 4
Urokinase-type plasminogen activator and Trypsin-1 inhibitor A... 1 6
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
Trace amine-associated receptor 1 ligand ZINC07609882 family 2 0
Caspase-3 inhibitor AGN-PC-00ELYM family 3 2
Mitogen-activated protein kinase 14 inhibitor SureCN4222090 fa... 1 12
Dual specificity mitogen-activated protein kinase kinase 1 inh... 8 3
Dual specificity mitogen-activated protein kinase kinase 1 inh... 9 1
Dual specificity mitogen-activated protein kinase kinase 1 inh... 3 0
Progesterone receptor ligand AGN-PC-00PB7I family 1 5
Histone deacetylase 1 and Histone deacetylase 2 inhibitor Sure... 2 0
NP (s)-3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepi... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00379108 CHEMBL1669669 Bioactive EPPTB
CFAMM00379107 CHEMBL1669665 Bioactive AGN-PC-04XAJ1
CFAMM00379105 CHEMBL1669672 Bioactive AGN-PC-04XARG
CFAMM00379102 CHEMBL2031574 Bioactive 4-(4-fluorophenyl)-N-[3-(pyrrolidin-1-ylmethyl)-2H-chromen-7-yl]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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