CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7329
Family Name Sigma non-opioid intracellular receptor 1 and D(2) dopamine receptor ligand SureCN12673206 family
No. of Seeds 11 No. of Other Members 2
Family Centroid CFAMM00379164 Functional Category Bioactive
Superfamily Histamine H1 receptor Ligand Doxepin Superfamily
Class Class 142

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Opioid receptor ligand opiate Levorphanol Family 18 537
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Mu-type opioid receptor Ligand Alvimopan Family 32 325
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
Dapoxetine family 3 40
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Peptide deformylase, mitochondrial Inhibitor Tylophorinidine F... 7 1
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Histamine H3 receptor Ligand A-349821 Family 49 228
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 18 25
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand Cyprodime Family 12 8
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 6
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 12
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
D(3) dopamine receptor ligand S 14297 family 1 2
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 4
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 2
Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Histamine H3 receptor ligand SureCN5093910 family 3 16
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 6 1
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 1-(4-... 2 3
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-(4-methoxyphenox... 2 1
Transporter and 5-hydroxytryptamine receptor 2C ligand CHEMBL1... 5 5
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
Histamine H3 receptor ligand SureCN6071181 family 2 1
Sodium-dependent serotonin transporter and Alpha-2A adrenergic... 2 2
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Somatostatin receptor type 1 and D(4) dopamine receptor ligand... 9 10
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 7 1
Alpha-1A adrenergic receptor ligand 3-[[2-(4-hydroxy-5-methyl-... 1 4
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Substance-P receptor ligand SureCN8415737 family 3 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 0
Transporter and Sodium-dependent serotonin transporter inhibit... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Cathepsin B and Cathepsin S inhibitor (4S,5R)-4-(2,3-dimethylp... 1 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 3
Neuromedin-K receptor ligand SureCN2478117 family 1 0
5-hydroxytryptamine receptor 1A ligand (Z)-1-diazonio-3-[[7-(d... 1 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-006SR... 1 2
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 1 0
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0
Sigma non-opioid intracellular receptor 1 ligand tert-butyl 2-... 1 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 1
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 2 0
Putative NP ZINC04061066 Family 18 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00379164 CHEMBL306365 Bioactive SureCN12673206
CFAMM00379170 CHEMBL77220 Bioactive 1-cyclohexyl-4-[4-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)butyl]piperazine
CFAMM00379163 CHEMBL74858 Bioactive AGN-PC-008GIQ
CFAMM00379169 CHEMBL1672037 Bioactive AGN-PC-08Y2O6
CFAMM00379168 CHEMBL1672038 Bioactive 1-cyclohexyl-4-[2-[[(1R)-5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]oxy]ethyl]piperazine
CFAMM00379161 CHEMBL573234 Bioactive AGN-PC-077XGN
CFAMM00379167 CHEMBL1672039 Bioactive 1-cyclohexyl-4-[2-[[(1S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]oxy]ethyl]piperazine
CFAMM00379173 CHEMBL73854 Bioactive 1-cyclohexyl-4-[3-[(1R)-5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]propyl]piperazine
CFAMM00379166 CHEMBL75878 Bioactive AGN-PC-0094UV
CFAMM00379172 CHEMBL74811 Bioactive AGN-PC-005X6G
CFAMM00379165 CHEMBL419822 Bioactive 1-cyclohexyl-4-[3-[(1S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]propyl]piperazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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