CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7333
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform inhibitor AGN-PC-09QKNA family
No. of Seeds 6 No. of Other Members 12
Family Centroid CFAMM00163239 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Binder Superfamily
Class Class 481

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Histamine H1 receptor Ligand Mepyramine Family 5 65
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 31
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
AP26113 family 16 90
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
RAC-gamma serine/threonine-protein kinase Inhibitor GSK690693 ... 16 27
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 6
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-07YOWS family 4 6
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 11 2
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Toll-like receptor 7 ligand 4-amino-1-[[6-(2-pyrrolidin-1-ylet... 2 5
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 2
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 7 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
ALK tyrosine kinase receptor ligand CHEMBL1946804 family 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 6 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 1
Glucose-dependent insulinotropic receptor ligand (2R)-2-[1-(5-... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Transient receptor potential cation channel subfamily V member... 2 4
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Diacylglycerol O-acyltransferase 1 inhibitor 4-[5-[5-(1H-benzi... 7 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
Metabotropic glutamate receptor 5 ligand N-[2-[(3-chlorophenyl... 1 4
Corticotropin-releasing factor receptor 1 ligand N-[(1R,2S)-2-... 3 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 2 0
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-073... 1 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00379193 CHEMBL470396 Bioactive SureCN6368598
CFAMM00379206 CHEMBL1672326 Bioactive AGN-PC-09QKN9
CFAMM00379205 CHEMBL1672327 Bioactive AGN-PC-09QLOE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543