CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM734
Family Name D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one family
No. of Seeds 12 No. of Other Members 14
Family Centroid CFAMM00314830 Functional Category Bioactive
Superfamily D(2) dopamine receptor and Renin Binder Superfamily
Class Class 3218

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand quinolone derivative Carteolol... 1 38
D(2) dopamine receptor ligand phenylpiperazine derivative Arip... 3 53
SUR1-type K(ATP) channel and SUR2-type K(ATP) channel Ligand R... 1 16
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
D(2) dopamine receptor Ligand Aplindore Fumarate Family 2 30
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Beta-2 adrenergic receptor Ligand Olodaterol Family 16 27
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand Du 125530 Family 2 0
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 20
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cannabinoid receptor 2 ligand 8-butoxy-N-(2-fluoro-2-phenyleth... 12 7
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Microsomal triglyceride transfer protein large subunit inhibit... 4 5
Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]pro... 3 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 8 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-01ZLS4 family 2 8
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 3 1
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2I family 3 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Trace amine-associated receptor 1 ligand EPPTB family 4 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 5
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Galanin receptor type 3 and Alpha-1A adrenergic receptor ligan... 2 16
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Poly [ADP-ribose] polymerase 1 inhibitor 3-chloro-N-cyclopropy... 1 2
Poly [ADP-ribose] polymerase 1 inhibitor N-ethyl-4-[4-[(8-meth... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor 6-[[4-(4-chlorophenyl... 1 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 3
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 7 1
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 10 2
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 4 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-(3-methoxy-2-me... 2 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Hormone-sensitive lipase inhibitor [4-[(4-tert-butylcyclohexan... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 2
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 2 0
Beta-lactamase and 4'-phosphopantetheinyl transferase ffp inhi... 1 0
Putative NP ZINC04030010 Family 8 3
NP (s)-3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepi... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00314830 CHEMBL443034 Bioactive 7-[4-[4-(2-ethoxyphenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
CFAMM00314816 CHEMBL1087452 Bioactive AGN-PC-07ZFH2
CFAMM00314815 CHEMBL1087453 Bioactive AGN-PC-07ZFH3
CFAMM00314814 CHEMBL1087454 Bioactive AGN-PC-07ZFH4
CFAMM00314820 CHEMBL160296 Bioactive 7-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
CFAMM00314813 CHEMBL160744 Bioactive 7-[4-[4-(2,3-dimethylphenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
CFAMM00314819 CHEMBL2165121 Bioactive 7-[4-[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22071 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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