CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM735
Family Name Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family
No. of Seeds 3 No. of Other Members 16
Family Centroid CFAMM00314836 Functional Category Bioactive with Natural Product
Superfamily Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 Binder Superfamily
Class Class 3140

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Nemonapride Family 70 283
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
Coagulation factor X Inhibitor BMS-269223 Family 15 58
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 1 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Disintegrin and metalloproteinase domain-containing protein 17... 3 0
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-087THW family 1 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Microsomal triglyceride transfer protein large subunit inhibit... 4 5
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 2
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Trace amine-associated receptor 1 ligand EPPTB family 4 9
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 0
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Motilin receptor ligand SureCN14564469 family 1 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Cathepsin S and Cathepsin K inhibitor SureCN3018173 family 2 4
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 1
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 3 11
Bifunctional epoxide hydrolase 2 and RAF proto-oncogene serine... 4 10
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-ethylbutanoyl)... 11 0
Diacylglycerol O-acyltransferase 1 inhibitor (1R,2R)-2-[4-[3-f... 2 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 11 4
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJY family 5 4
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KFD family 1 1
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
Hormone-sensitive lipase inhibitor [4-[(4-tert-butylcyclohexan... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Trypsin-1 inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethylam... 1 0
Proteinase-activated receptor 1 ligand 2-[[2-[[2-[acetyl-[(E)-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00314845 CHEMBL1087491 Bioactive AGN-PC-04UEH2
CFAMM00314836 CHEMBL1088545 Bioactive AGN-PC-04UEH3
CFAMM00314835 CHEMBL1088547 Bioactive AGN-PC-04UEJ5

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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