CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7372
Family Name Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[4-(benzenesulfonyl)-1-oxothiane-4-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acid family
No. of Seeds 12 No. of Other Members 20
Family Centroid CFAMM00189360 Functional Category Bioactive
Superfamily Integrin beta-1 and Integrin alpha-4 Binder Superfamily 8
Class Class 590

Cousin Family NamesSeedsMembers
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Integrin alpha-4 Inhibitor Firategrast Family 3 93
Vasopeptidase Inhibitor Fasidotril Family 3 7
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Trypsin Inhibitor Benzamidrazone Analogue Family 2 6 38
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6368456 f... 3 23
Integrin beta-1 and Integrin alpha-4 inhibitor (3R)-3-[[(2S)-1... 12 0
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6367561 f... 20 12
Neprilysin inhibitor SureCN389939 family 5 6
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5686971 f... 19 1
Integrin beta-1 and Integrin alpha-4 inhibitor AGN-PC-074GDW f... 9 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-ethy... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(3-benz... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[1-(ben... 6 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 9 2
Integrin beta-1 and Integrin alpha-4 inhibitor (4S)-4-[benzene... 7 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 16 23
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
72 kDa type IV collagenase and Neutrophil collagenase inhibito... 12 20
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5686827 f... 7 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-2... 2 21
72 kDa type IV collagenase and Collagenase 3 inhibitor 2-[(3Z)... 4 3
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 5 2
Neprilysin inhibitor benzyl (2S)-3-(4-hydroxyphenyl)-2-[[2-(su... 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 4 1
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5687185 f... 7 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 1 0
Integrin alpha-4 and Integrin beta-7 inhibitor (2S)-2-[[[(2S)-... 2 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00379433 CHEMBL353589 Bioactive (2S)-2-[[3-(benzenesulfonyl)piperidine-3-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acid
CFAMM00379446 CHEMBL171507 Bioactive (2S)-2-[[1-(4-fluorophenyl)sulfonylcyclohexanecarbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acid
CFAMM00379452 CHEMBL169530 Bioactive (2S)-2-[[3-(benzenesulfonyl)-1-methylpiperidine-3-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acid
CFAMM00379451 CHEMBL171284 Bioactive (2S)-2-[[4-(benzenesulfonyl)-1-methylpiperidine-4-carbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acid
CFAMM00379450 CHEMBL423443 Bioactive (2S)-3-[4-(2-methoxyphenyl)phenyl]-2-[[1-(3-methylphenyl)sulfonylcyclohexanecarbonyl]amino]propanoic acid
CFAMM00379443 CHEMBL171481 Bioactive (2S)-3-[4-(2-methoxyphenyl)phenyl]-2-[[1-(4-methylphenyl)sulfonylcyclohexanecarbonyl]amino]propanoic acid
CFAMM00379454 CHEMBL353016 Bioactive (2S)-2-[[1-(4-chlorophenyl)sulfonylcyclohexanecarbonyl]amino]-3-[4-(2-methoxyphenyl)phenyl]propanoic acid
CFAMM00379447 CHEMBL354798 Bioactive (2S)-3-[4-(2-methoxyphenyl)phenyl]-2-[[1-(2-methylphenyl)sulfonylcyclohexanecarbonyl]amino]propanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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