CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7378
Family Name Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA family
No. of Seeds 3 No. of Other Members 4
Family Centroid CFAMM00379494 Functional Category Bioactive
Superfamily Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 Binder Superfamily 2
Class Class 24

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Epidermal growth factor receptor and Receptor tyrosine-protein... 16 89
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
Tivozanib family 4 6
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 6 8
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Proto-oncogene tyrosine-protein kinase Src inhibitor N-(2,4-di... 3 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 7
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Receptor-type tyrosine-protein kinase FLT3 ligand 2-(6,7-dimet... 3 2
Vascular endothelial growth factor receptor 2 and Vascular end... 3 3
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 0
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS94Q ... 6 0
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN4... 9 2
Hepatocyte growth factor receptor ligand 1-(2-chlorophenyl)-N-... 14 8
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 0
Protein kinase C theta type inhibitor AGN-PC-04SQV8 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00379495 CHEMBL421440 Bioactive AC1NS5MD
CFAMM00379494 CHEMBL168146 Bioactive AC1NS5MA
CFAMM00379492 CHEMBL339770 Bioactive AC1NS5NJ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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