CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7379
Family Name Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHYL-1-PHENYLCARBAMOYL-BUTYLCARBAMOYL)-2-[4-(1-OXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BUTYL]-HEXANOIC ACID family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00379498 Functional Category Bioactive
Superfamily Integrin beta-3 Inhibitor Lotrafiban Superfamily
Class Class 1675

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Cholecystokinin receptor type A Ligand Gi 181771 Family 3 18
Integrin beta-1 Inhibitor R411 Family 33 44
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor L-709780 Family 9 10
Integrin beta-3 Inhibitor L-750034 Family 7 38
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Integrin beta-3 Inhibitor Lotrafiban Family 5 1
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Protein kinase C eta type and Protein kinase C delta type Inhi... 9 12
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Beta-secretase 1 Inhibitor KMI-538 Family 4 20
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Leukotriene A-4 hydrolase Inhibitor SA-6541 Family 4 32
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Caspase-1 inhibitor CHEMBL114791 family 1 0
Angiotensin-converting enzyme inhibitor (2R)-1-[4-carboxy-4-(p... 3 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Pol polyprotein inhibitor Lysine Sulfonamide 11o family 2 6
Mitogen-activated protein kinase 1 and M17 leucyl aminopeptida... 1 21
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7285564... 1 2
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Dipeptidyl peptidase 4 inhibitor SureCN1499864 family 4 7
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
Prostaglandin E2 receptor EP4 subtype ligand SureCN3567929 family 10 3
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Kappa-type opioid receptor ligand 4-[3-[(1S)-1-[methyl-[2-[4-(... 1 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-1-... 3 3
Angiotensin-converting enzyme inhibitor 1-[(2R,4R)-4-carboxy-2... 2 3
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-037CNR f... 5 8
Atrial natriuretic peptide receptor 1 and Atrial natriuretic p... 3 0
Neprilysin inhibitor SureCN7437961 family 2 6
Dihydrofolate reductase inhibitor AGN-PC-073POJ family 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[4-[2-[... 1 0
Coagulation factor X and Tissue factor inhibitor AGN-PC-02WN8Y... 7 22
Neprilysin and Angiotensin-converting enzyme inhibitor 3-[(3S)... 1 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00379499 CHEMBL168150 Bioactive (2S,4R)-4-[[(2S)-1-anilino-4-methyl-1-oxopentan-2-yl]carbamoyl]-2-[4-(3-oxo-1H-isoindol-2-yl)butyl]-6-(4-propylphenyl)hexanoic acid
CFAMM00379498 CHEMBL8933 Bioactive 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHYL-1-PHENYLCARBAMOYL-BUTYLCARBAMOYL)-2-[4-(1-OXO-1,3-DIHYDRO-ISOINDOL-2-YL)-BUTYL]-HEXANOIC ACID

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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