CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7384
Family Name Vascular endothelial growth factor receptor 2 ligand 1-[4-[6-amino-5-[(E)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-phenylurea family
No. of Seeds 11 No. of Other Members 13
Family Centroid CFAMM00379540 Functional Category Bioactive
Superfamily Vascular endothelial growth factor receptor 2 and Cruzipain Binder Superfamily
Class Class 4129

Cousin Family NamesSeedsMembers
Nuclear factor NF-kappa-B p100 subunit Inhibitor GMX1777 Family 3 7
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
AP26113 family 16 90
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 and Fibroblast g... 3 11
Vascular endothelial growth factor receptor 2 and Fibroblast g... 10 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Vascular endothelial growth factor receptor 2 ligand 1-[4-[6-a... 2 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Corticotropin-releasing factor receptor 1 ligand N-butyl-9-(2-... 4 5
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro... 7 1
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 5 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Receptor tyrosine-protein kinase erbB-2 ligand 2-[2-[4-[3-chlo... 4 5
Wee1-like protein kinase and ALK tyrosine kinase receptor liga... 1 9
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 0
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 3
Tyrosine-protein kinase receptor Tie-1 and Receptor-type tyros... 1 0
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 4
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 2 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 1
Vascular endothelial growth factor receptor 2 ligand SureCN472... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00379538 CHEMBL1681941 Bioactive 1-[4-[6-amino-5-[(E)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-pyridin-3-ylurea
CFAMM00379551 CHEMBL1681951 Bioactive 1-[4-[6-amino-5-[(E)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-(3-fluorophenyl)urea
CFAMM00379537 CHEMBL1681948 Bioactive 1-[4-[6-amino-5-[(E)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-(2-methylphenyl)urea
CFAMM00379550 CHEMBL1681950 Bioactive 1-[4-[6-amino-5-[(E)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-(2-fluorophenyl)urea
CFAMM00379536 CHEMBL1681949 Bioactive 1-[4-[6-amino-5-[(E)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-(2-methoxyphenyl)urea
CFAMM00379548 CHEMBL1681955 Bioactive 1-[4-[6-amino-5-[(E)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-cyclohexylurea
CFAMM00379541 CHEMBL1681945 Bioactive 1-[4-[6-amino-5-[(E)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea
CFAMM00379553 CHEMBL1681953 Bioactive 1-[4-[6-amino-5-[(E)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-(2,4-difluorophenyl)urea
CFAMM00379540 CHEMBL1681946 Bioactive 1-[4-[6-amino-5-[(E)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-phenylurea
CFAMM00379539 CHEMBL1681947 Bioactive 1-[4-[6-amino-5-[(E)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-(2-chlorophenyl)urea
CFAMM00379552 CHEMBL1681952 Bioactive 1-[4-[6-amino-5-[(E)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-(4-fluorophenyl)urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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