CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7388
Family Name Microsomal triglyceride transfer protein large subunit inhibitor 9-[4-[2-methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamide family
No. of Seeds 7 No. of Other Members 4
Family Centroid CFAMM00379598 Functional Category Bioactive
Superfamily CC-486 Superfamily
Class Class 716

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
Histamine H1 receptor Ligand Mizolastine Family 14 603
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
JAK Inhibitor Momelotinib Family 33 83
Eluxadoline family 4 85
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 9
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 5 13
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
C-C chemokine receptor type 5 ligand [4-[2-[3-(2-ethylbenzimid... 5 12
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
C-C chemokine receptor type 5 ligand SureCN13543564 family 10 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 29
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
C-C chemokine receptor type 5 ligand 1-[4-(3-chlorophenyl)-4-[... 3 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Glucagon receptor ligand SureCN2666184 family 7 2
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Melanin-concentrating hormone receptor 1 ligand SureCN3832854 ... 3 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Corticotropin-releasing factor receptor 2 and Corticotropin-re... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00379597 CHEMBL354076 Bioactive N-(2,2,2-trifluoroethyl)-9-[3-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]propyl]fluorene-9-carboxamide
CFAMM00379596 CHEMBL355007 Bioactive UNII-0Z473OO6GB
CFAMM00379595 CHEMBL353385 Bioactive N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]fluorene-9-carboxamide
CFAMM00379593 CHEMBL168680 Bioactive 9-[4-[2-propan-2-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamide
CFAMM00379599 CHEMBL355892 Bioactive 9-[4-[5-methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamide
CFAMM00379592 CHEMBL353483 Bioactive 9-[4-[2-propyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamide
CFAMM00379598 CHEMBL168216 Bioactive 9-[4-[2-methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzimidazol-1-yl]butyl]-N-(2,2,2-trifluoroethyl)fluorene-9-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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