CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7395
Family Name Glucocorticoid receptor ligand SureCN5650626 family
No. of Seeds 17 No. of Other Members 25
Family Centroid CFAMM00379664 Functional Category Bioactive with Human Metabolite
Superfamily Gamma-aminobutyric acid receptor subunit alpha-1 Ligand (6-benzylamino-9h-beta-carbolin-3-yl)-methanol Superfamily
Class Class 2748

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Food vacuoles Inhibitor Mefloquine Family 2 25
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Grt 6005/06 family 4 22
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand (6-ben... 2 5
D(1B) dopamine receptor and D(2) dopamine receptor Ligand Flut... 1 6
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Protein kinase C theta type and Protein kinase C delta type in... 16 8
Progesterone receptor and Glucocorticoid receptor ligand SureC... 4 2
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 10 9
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 4 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 7 14
Glucocorticoid receptor and Progesterone receptor ligand [(3R,... 6 2
Glucocorticoid receptor ligand SureCN4198717 family 5 0
Glucocorticoid receptor ligand SureCN4204659 family 2 0
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Glucocorticoid receptor ligand AGN-PC-0A9RHA family 1 2
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[2-(1H-ind... 1 0
Melanin-concentrating hormone receptor 2 ligand (2R)-1'-(9H-ca... 2 10
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Transporter and Sodium-dependent serotonin transporter inhibit... 2 1
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 5 8
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
Beta-3 adrenergic receptor ligand 3-[2-[[(2R)-2-(3-chloropheny... 1 1
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand RU-2... 3 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 3 9
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00379676 CHEMBL1682435 Bioactive (3R,4S)-7-ethenyl-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-3,4-dihydro-1H-quinolin-3-ol
CFAMM00379668 CHEMBL1682426 Bioactive (3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-5-[(E)-phenylmethoxyiminomethyl]-3,4-dihydro-1H-quinolin-3-ol
CFAMM00379661 CHEMBL1682428 Bioactive (E)-3-[(3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-3,4-dihydro-1H-quinolin-5-yl]prop-2-enenitrile
CFAMM00379675 CHEMBL1682437 Bioactive (3R,4S)-7,8-difluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-3,4-dihydro-1H-quinolin-3-ol
CFAMM00379667 CHEMBL1682424 Bioactive (3R,4S)-5-[(E)-ethoxyiminomethyl]-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-3,4-dihydro-1H-quinolin-3-ol
CFAMM00379682 CHEMBL1682419 Bioactive SureCN5502951
CFAMM00379660 CHEMBL1682429 Bioactive SureCN5499342
CFAMM00379674 CHEMBL1682430 Bioactive (E)-4-[(3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-3,4-dihydro-1H-quinolin-5-yl]but-3-en-2-one
CFAMM00379689 CHEMBL1760023 Bioactive AGN-PC-093IQQ
CFAMM00379666 CHEMBL1682425 Bioactive (3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethyl-5-[(E)-(2-methylpropan-2-yl)oxyiminomethyl]-3,4-dihydro-1H-quinolin-3-ol
CFAMM00379681 CHEMBL1682418 Bioactive SureCN5653268
CFAMM00379673 CHEMBL1682432 Bioactive SureCN4190823
CFAMM00379665 CHEMBL1682423 Bioactive (3R,4S)-6-(1H-indol-7-yl)-5-[(E)-methoxyiminomethyl]-2,2,4,8-tetramethyl-3,4-dihydro-1H-quinolin-3-ol
CFAMM00379672 CHEMBL1682438 Bioactive (3R,4S)-5,7,8-trifluoro-6-(1H-indol-7-yl)-2,2,4-trimethyl-3,4-dihydro-1H-quinolin-3-ol
CFAMM00379664 CHEMBL1682420 Bioactive SureCN5650626
CFAMM00379693 CHEMBL1682441 Bioactive SureCN4191027

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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