CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7399
Family Name Neuromedin-K receptor ligand (1S,2R)-1-(3,4-dichlorophenyl)-N-[(4-fluorophenyl)methyl]-N-methyl-2-[[4-(2-piperidin-1-ylacetyl)piperazin-1-yl]methyl]cyclopropane-1-carboxamide family
No. of Seeds 8 No. of Other Members 0
Family Centroid CFAMM00379717 Functional Category Bioactive
Superfamily Neuromedin-K receptor Ligand Osanetant Superfamily
Class Class 908

Cousin Family NamesSeedsMembers
Neuromedin-K receptor Ligand Osanetant Family 38 192
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Substance-P receptor ligand AGN-PC-075NUD family 4 1
Substance-P receptor ligand 4-[1-[2-[1-(cyclopropylmethyl)-3-(... 10 6
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 9 0
Substance-K receptor ligand (5S)-1-(2-cyclopropylethyl)-5-(3,4... 10 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 5 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 3 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 2 0
Substance-P receptor ligand 1-(cyclohexylmethyl)-5-(3,4-dichlo... 8 1
Prostaglandin D2 receptor 2 ligand SureCN4942606 family 2 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 6 0
Substance-K receptor ligand SureCN3083325 family 4 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[(3,4-dichlo... 1 0
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00379716 CHEMBL1682676 Bioactive (1S,2R)-1-(3,4-dichlorophenyl)-N-[(4-fluorophenyl)methyl]-N-methyl-2-[[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]methyl]cyclopropane-1-carboxamide
CFAMM00379715 CHEMBL1682675 Bioactive (1S,2R)-1-(3,4-dichlorophenyl)-N-[(4-fluorophenyl)methyl]-N-methyl-2-[[4-(2-morpholin-4-ylethyl)piperazin-1-yl]methyl]cyclopropane-1-carboxamide
CFAMM00379714 CHEMBL1682674 Bioactive (1S,2R)-1-(3,4-dichlorophenyl)-N-[(4-fluorophenyl)methyl]-N-methyl-2-[[4-(2-morpholin-4-ylacetyl)piperazin-1-yl]methyl]cyclopropane-1-carboxamide
CFAMM00379720 CHEMBL1682682 Bioactive (1S,2R)-2-[[4-[2-(azepan-1-yl)acetyl]piperazin-1-yl]methyl]-1-(3,4-dichlorophenyl)-N-[(4-fluorophenyl)methyl]-N-methylcyclopropane-1-carboxamide
CFAMM00379719 CHEMBL1682683 Bioactive (1S,2R)-1-(3,4-dichlorophenyl)-2-[[3-[4-(dimethylsulfamoyl)piperazin-1-yl]azetidin-1-yl]methyl]-N-[(4-fluorophenyl)methyl]-N-methylcyclopropane-1-carboxamide
CFAMM00379718 CHEMBL1682681 Bioactive (1S,2R)-1-(3,4-dichlorophenyl)-N-[(4-fluorophenyl)methyl]-N-methyl-2-[(4-pyrrolidin-1-ylsulfonylpiperazin-1-yl)methyl]cyclopropane-1-carboxamide
CFAMM00379717 CHEMBL1682678 Bioactive (1S,2R)-1-(3,4-dichlorophenyl)-N-[(4-fluorophenyl)methyl]-N-methyl-2-[[4-(2-piperidin-1-ylacetyl)piperazin-1-yl]methyl]cyclopropane-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543