CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM74
Family Name Pol polyprotein inhibitor AC1LAD48 family
No. of Seeds 19 No. of Other Members 5
Family Centroid CFAMM00306731 Functional Category Bioactive
Superfamily HIV-1 protease Inhibitor Atazanavir Superfamily
Class Class 137

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
HIV-1 protease Inhibitor Atazanavir Family 16 58
Renin Inhibitor Remikiren Family 100 126
Coagulation factor X Inhibitor Otamixaban Family 9 21
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
CP-18770 family 6 27
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Renin Inhibitor Zankiren Family 32 50
Endothelin B receptor Ligand IRL-2500 Family 34 87
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Pol polyprotein inhibitor (2S)-N-[(2S,4S,5S)-4-hydroxy-5-[[(2S... 1 3
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Renin and Cathepsin D inhibitor tert-butyl N-[(2R)-1-[[3-[[(2R... 19 4
Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5
Pol polyprotein inhibitor N-[3-[[(4R,5R,6R)-4-benzyl-5-hydroxy... 1 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
Renin and Pepsin A inhibitor [(2S)-1-[[(2R)-1-[[(2S,3R)-1-cycl... 2 2
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
Pol polyprotein inhibitor BEJ family 2 0
Pol polyprotein and Protease inhibitor Palinavir family 1 0
Renin inhibitor propan-2-yl (3R)-2-hydroxy-3-[[(2S)-3-(1H-imid... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 4
C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Renin inhibitor (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-meth... 3 4
Pol polyprotein inhibitor (2R,3R,4R,5S)-5-[[(2S)-2-[5-[(4R,6aS... 1 0
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-075FXA f... 1 0
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
Pol polyprotein inhibitor AC1LAHRX family 4 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Renin inhibitor (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-d... 3 0
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7013744... 2 3
Metabotropic glutamate receptor 5 ligand AGN-PC-09SALK family 2 15
Renin inhibitor (2S)-N-[(2S,3S)-1-cyclohexyl-3-hydroxy-5-(3-im... 4 0
Pol polyprotein inhibitor 183854-98-0 family 15 2
Pol polyprotein inhibitor Cyclic Urea 68 family 4 0
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Pol polyprotein inhibitor AC1LALGZ family 2 14
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Pol polyprotein inhibitor 183854-15-1 family 3 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Pol polyprotein inhibitor [(2R,3R)-1,1-dioxo-2-propan-2-ylthio... 11 0
Renin inhibitor tert-butyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl-3,4... 2 2
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Pol polyprotein inhibitor (2S)-N-[(2S,3S,4S,5S)-5-[[(2R)-2-[[(... 2 1
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Beta-secretase 1 and Cathepsin B inhibitor SureCN14347784 family 4 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 1 0
Pol polyprotein inhibitor AC1LA6OV family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00306739 CHEMBL109992 Bioactive (2S)-N-[(2S,3R,4S,5S)-3,4-dihydroxy-5-[[(2R)-3-methyl-2-(2-pyridin-2-ylethylsulfonylamino)butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-pyridin-2-ylethylsulfonylamino)butanamide
CFAMM00306719 CHEMBL323955 Bioactive (2S)-N-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2R)-3-methyl-2-[[methyl(2-pyridin-2-ylethyl)carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-[[methyl(2-pyridin-2-ylethyl)carbamoyl]amino]butanamide
CFAMM00306732 CHEMBL323809 Bioactive (2S)-N-[(2S,3S,4R,5S)-3,4-dihydroxy-5-[[(2R)-3-methyl-2-[[methyl(pyridin-3-ylmethyl)carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-[[methyl(pyridin-3-ylmethyl)carbamoyl]amino]butanamide
CFAMM00306725 CHEMBL299124 Bioactive AC1NBNWV
CFAMM00306731 CHEMBL10113 Bioactive AC1LAD48
CFAMM00306718 CHEMBL111388 Bioactive (2R)-N-[(2S,3S,4S,5S)-3,4-dihydroxy-5-[[(2S)-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-[[methyl(pyridin-3-ylmethyl)carbamoyl]amino]butanamide
CFAMM00306724 CHEMBL112930 Bioactive (2S)-N-[(2S,3S,4R,5S)-3,4-dihydroxy-5-[[(2R)-3-methyl-2-(2-pyridin-2-ylethylsulfonylamino)butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-pyridin-2-ylethylsulfonylamino)butanamide
CFAMM00306737 CHEMBL2051986 Bioactive SureCN8749867
CFAMM00306717 CHEMBL333601 Bioactive (2S)-N-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2R)-3-methyl-2-[[methyl(pyridin-3-ylmethyl)carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-[[methyl(pyridin-3-ylmethyl)carbamoyl]amino]butanamide
CFAMM00306730 CHEMBL43294 Bioactive A-76889
CFAMM00306736 CHEMBL269401 Bioactive AC1LAD45
CFAMM00306716 CHEMBL112578 Bioactive (2S)-N-[(2S,3R,4S,5S)-3,4-dihydroxy-5-[[(2R)-3-methyl-2-(2-pyridin-4-ylethylsulfonylamino)butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-pyridin-4-ylethylsulfonylamino)butanamide
CFAMM00306729 CHEMBL113575 Bioactive (2R)-N-[(2S,3S,4R,5S)-3,4-dihydroxy-5-[[(2S)-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamide
CFAMM00306722 CHEMBL322477 Bioactive (2S)-N-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2R)-3-methyl-2-(2-pyridin-2-ylethylsulfonylamino)butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-pyridin-2-ylethylsulfonylamino)butanamide
CFAMM00306735 CHEMBL113377 Bioactive (2S)-N-[(2S,3S,4R,5S)-3,4-dihydroxy-5-[[(2R)-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamide
CFAMM00306721 CHEMBL111957 Bioactive (2S)-N-[(2S,3R,4S,5S)-3,4-dihydroxy-5-[[(2R)-3-methyl-2-[[(E)-3-pyridin-3-ylprop-2-enoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-[[(E)-3-pyridin-3-ylprop-2-enoyl]amino]butanamide
CFAMM00306734 CHEMBL331363 Bioactive (2R)-N-[(2S,3S,4R,5S)-3,4-dihydroxy-5-[[(2S)-3-methyl-2-[[methyl(pyridin-3-ylmethyl)carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-[[methyl(pyridin-3-ylmethyl)carbamoyl]amino]butanamide
CFAMM00306727 CHEMBL112138 Bioactive (2S)-N-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2R)-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]-3-methyl-2-[[methyl(pyridin-2-ylmethyl)carbamoyl]amino]butanamide
CFAMM00306733 CHEMBL330474 Bioactive (2R)-4-(4-aminopiperidin-1-yl)-2-benzyl-N-[(2R)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-pyridin-2-ylhexan-2-yl]amino]-3-methylsulfanyl-1-oxopropan-2-yl]-4-oxobutanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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