CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM741
Family Name Prolyl endopeptidase inhibitor [(2S,3aS,7aS)-2-(pyrrole-1-carbonyl)-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-[(1R,2R)-2-phenylcyclopropyl]methanone family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00314868 Functional Category Bioactive
Superfamily Sodium channel protein type 5 subunit alpha Ligand Disopyramide Superfamily
Class Class 295

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Prothrombin Inhibitor Ximelegatran Family 8 157
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Substance-P receptor Ligand GSK424887 Family 8 184
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
FK506-binding protein 1A Inhibitor Gpi-1046 Family 4 10
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Histone deacetylase Inhibitor ST-5732 Family 8 6
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Cycl... 7 6
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor S-(3-pyri... 1 6
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Disintegrin and metalloproteinase domain-containing protein 17... 3 3
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Dipeptidyl peptidase 4 inhibitor (2S)-1-[2-[5-(aminomethyl)-2-... 4 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Glycogen synthase kinase-3 beta inhibitor 3-(2-bromoacetyl)-4-... 1 0
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Androgen receptor ligand CHEMBL181722 family 1 1
Proto-oncogene Wnt-3 inhibitor CHEMBL563202 family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00314867 CHEMBL80770 Bioactive [(2S,3aS,7aS)-2-(pyrrole-1-carbonyl)-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-[(1R,2S)-2-phenylcyclopropyl]methanone
CFAMM00314868 CHEMBL1087607 Bioactive [(2S,3aS,7aS)-2-(pyrrole-1-carbonyl)-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-[(1R,2R)-2-phenylcyclopropyl]methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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