CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7417
Family Name Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenylpropyl]-2-thiophen-2-ylquinoline-4-carboxamide family
No. of Seeds 3 No. of Other Members 5
Family Centroid CFAMM00379881 Functional Category Bioactive
Superfamily Macrophage metalloelastase Inhibitor PF-00356231 Superfamily
Class Class 1827

Cousin Family NamesSeedsMembers
Neuromedin-K receptor Ligand SB222200 Family 17 235
D(3) dopamine receptor Ligand SB-277011 Family 13 178
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
Cysteine protease and Cruzipain inhibitor N-[(E,3S)-1-(benzene... 1 1
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 2 14
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1367658 ... 1 7
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1231206 ... 6 7
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Cellular tumor antigen p53 and Ferritin light chain inhibitor ... 1 2
Nuclear receptor ROR-gamma and Niemann-Pick C1 protein ligand ... 1 12
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
Serine/threonine-protein kinase D3 and Protein kinase C delta ... 3 10
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QN2D family 2 2
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Histone deacetylase 1 inhibitor N-hydroxy-5-[1-[2-[(1-methylin... 4 1
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 5 5
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Cytochrome P450 2C9 inhibitor AGN-PC-04XDND family 1 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 2
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL3... 1 9


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00379874 CHEMBL1682950 Bioactive 3-methylsulfinyl-N-[(1S)-1-phenylpropyl]-2-thiophen-3-ylquinoline-4-carboxamide
CFAMM00379881 CHEMBL1682949 Bioactive 3-methylsulfinyl-N-[(1S)-1-phenylpropyl]-2-thiophen-2-ylquinoline-4-carboxamide
CFAMM00379880 CHEMBL1682965 Bioactive 7-bromo-3-methylsulfinyl-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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