CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7423
Family Name Pol polyprotein inhibitor CHEMBL305466 family
No. of Seeds 4 No. of Other Members 7
Family Centroid CFAMM00379935 Functional Category Bioactive
Superfamily Glucan synthesis regulatory protein Inhibitor Anidulafungin Superfamily
Class Class 322

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Endothelin-1 receptor Ligand Atrasentan Family 127 336
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Integrin alpha-4 Inhibitor Firategrast Family 3 93
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Tryptase Inhibitor APC-366 Family 2 12
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Pol polyprotein inhibitor 180968-31-4 family 8 13
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Caspase-1 inhibitor 5-(3-carbamoylnaphthalen-2-yl)oxy-3-[[(2S)... 1 11
D(2) dopamine receptor ligand 2-chloro-3-ethyl-N-[[(2S)-1-ethy... 3 0
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
Pol polyprotein inhibitor KNI-1279 family 3 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
B1 bradykinin receptor ligand 4-(5-chloro-4-oxochromen-3-yl)-N... 1 5
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 0
Caspase-1 and Caspase-8 inhibitor benzyl (4S,7S,9Z,11aS)-7-ben... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-d... 10 15
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Beta-secretase 1 and Cathepsin B inhibitor N-[(2S)-1-[[(2S,3R)... 2 1
Caspase-1 and Caspase-8 inhibitor N-[(6S)-1-[2-[[(3S)-2-hydrox... 3 1
Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)... 13 5
Pol polyprotein inhibitor SDZ PRI 053 family 8 1
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Sigma non-opioid intracellular receptor 1 and D(3) dopamine re... 26 8
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Pol polyprotein inhibitor AC1LALH8 family 2 1
Growth hormone secretagogue receptor type 1 ligand SureCN76477... 2 1
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
NS3 and Non-structural protein 4A inhibitor (4S)-4-[[(2S)-3-ca... 1 0
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04X9O... 2 1
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
C-C chemokine receptor type 3 ligand N-[(3R)-1-[(6-fluoronapht... 1 4
D(3) dopamine receptor ligand S33084 family 1 1
Sodium/hydrogen exchanger 1 inhibitor 4-(1-acetylpiperidin-4-y... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00379935 CHEMBL305466 Bioactive CHEMBL305466
CFAMM00379933 CHEMBL1683153 Bioactive 3-methoxy-N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)piperazin-1-yl]-1-phenylpentan-2-yl]carbamoyl]cyclopentyl]naphthalene-2-carboxamide
CFAMM00379939 CHEMBL70787 Bioactive CHEMBL70787

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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