CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7424
Family Name Prostaglandin E synthase inhibitor AGN-PC-09QHBK family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00379942 Functional Category Bioactive
Superfamily Transient receptor potential cation channel subfamily V member 1 Ligand A-425619 Superfamily
Class Class 825

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histamine H1 receptor Ligand Triprolidine Family 19 316
Prothrombin Inhibitor Ximelegatran Family 8 157
Transient receptor potential cation channel subfamily V member... 15 158
Transient receptor potential cation channel subfamily V member... 16 295
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Amg 423 family 7 47
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 9
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Cathepsin K inhibitor SureCN2155973 family 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Prostaglandin E synthase and Aldo-keto reductase family 1 memb... 3 12
Neuropeptide Y receptor type 5 ligand (5E)-5-[(4S,5S)-4-(4-flu... 18 3
Neuronal acetylcholine receptor subunit alpha-7 ligand 1-(4-me... 1 0
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 1 4
Transient receptor potential cation channel subfamily V member... 1 0
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Melanin-concentrating hormone receptor 1 ligand SureCN4917950 ... 3 5
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00379943 CHEMBL1683212 Bioactive AGN-PC-09QN7M
CFAMM00379942 CHEMBL1683213 Bioactive AGN-PC-09QHBK
CFAMM00379940 CHEMBL1683216 Bioactive AGN-PC-093IRZ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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