CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7429
Family Name Serine/threonine-protein kinase 17A and Myosin light chain kinase 3 inhibitor KW 2449 family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00042329 Functional Category Bioactive
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 18
Class Class 208

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Cannabinoid receptor 1 Ligand Rimonabant Family 20 260
Macrophage colony-stimulating factor 1 Inhibitor ABT-869 Family 8 56
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Cyclin-dependent kinase 2 Inhibitor N-(5-cyclopropyl-1h-pyrazo... 6 62
Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family 5 72
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(1h... 2 12
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
Orexin receptor type 2 and Orexin receptor type 1 ligand AGN-P... 7 19
Mitogen-activated protein kinase 14 and Mast/stem cell growth ... 4 4
Poly [ADP-ribose] polymerase 1 inhibitor 2-[2-[4-(1H-indazol-3... 1 0
5-hydroxytryptamine receptor 2A ligand AGN-PC-04RTMN family 7 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 3
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 2
5-hydroxytryptamine receptor 3A ligand SureCN8035577 family 5 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Mitogen-activated protein kinase 8 inhibitor (2S)-2-[[(2S)-2-[... 3 0
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
5-hydroxytryptamine receptor 3A ligand N-[(1S,5S)-9-methyl-9-a... 1 0
5-hydroxytryptamine receptor 3A ligand 1-[3-[[5-(dimethylamino... 1 1
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 3
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Calcitonin gene-related peptide type 1 receptor ligand 2-[(7-m... 3 0
5-hydroxytryptamine receptor 4 ligand N-[(1R,5S)-8-[2-hydroxy-... 4 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 2 1
5-hydroxytryptamine receptor 3A ligand 5-hydroxy-1-methyl-N-[(... 4 2
5-hydroxytryptamine receptor 4 ligand 4-[2-[4-[[(1-propan-2-yl... 1 1
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 5
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Rho-associated protein kinase 2 inhibitor 2-[(3S,4R)-4-(4-fluo... 9 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Serine/threonine-protein kinase PLK4 inhibitor 4-[(E)-2-[6-[(E... 2 3
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN4298966 f... 10 1
Serine/threonine-protein kinase Chk1 inhibitor 5-[(2S)-3-amino... 4 6
Serine/threonine-protein kinase Chk1 inhibitor PDK1 inhibitor,... 1 4
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Histone deacetylase 1 inhibitor N-hydroxy-N',N'-bis[2-(1H-inda... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor 2-(butylsulfo... 1 1
Cannabinoid receptor 1 ligand AGN-PC-07R5TU family 11 0
Serine/threonine-protein kinase D1 inhibitor 3-[5-[3-bromo-4-(... 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor py... 1 3
Rho-associated protein kinase 2 and Cytochrome P450 3A4 inhibi... 3 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00379985 CHEMBL1683435 Bioactive N-[(1R)-1-cyanoethyl]-3-[5-[4-[(propan-2-ylamino)methyl]phenyl]-1H-pyrazol-3-yl]benzamide
CFAMM00379990 CHEMBL349048 Bioactive N-(1-ethyl-4-methyl-1,4-diazepan-6-yl)-1H-indazole-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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