CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7437
Family Name Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)-1-[3-amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid family
No. of Seeds 17 No. of Other Members 19
Family Centroid CFAMM00380041 Functional Category Bioactive
Superfamily Seprase and Dipeptidyl peptidase 4 Binder Superfamily 4
Class Class 1297

Cousin Family NamesSeedsMembers
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
HIV-1 protease Inhibitor Lopinavir Family 4 25
Zucapsacin family 7 177
Thymopentin family 20 133
Serine/threonine-protein kinase PLK1 Inhibitor On Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Endothelin-1 receptor Ligand Atrasentan Family 127 336
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Kappa-type opioid receptor Ligand ICI-204448 Family 7 26
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Pol polyprotein inhibitor 180968-31-4 family 8 13
Prothrombin and Tissue-type plasminogen activator inhibitor CH... 10 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 5 4
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 3 2
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prostaglandin D2 receptor 2 ligand SureCN1713638 family 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-ethy... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6453971 f... 3 4
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 0
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Renin inhibitor (3S,6R)-6-(cyclohexylmethyl)-7-hydroxy-7-[[(2S... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Kappa-type opioid receptor ligand AGN-PC-075ED1 family 1 0
Kappa-type opioid receptor ligand N-[(1S)-2-[(3S)-3-hydroxypyr... 2 0


External ID

Functional Category

Molecule Name

CFAMM00380045 CHEMBL365836 Bioactive 2-[4-[[[(2S)-1-[3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]pentanoic acid;2,2,2-trifluoroacetic acid
CFAMM00380022 CHEMBL366048 Bioactive (2R)-2-[4-[[[(2S)-1-[3-amino-4-(2-chloro-4-fluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
CFAMM00380038 CHEMBL365838 Bioactive 2-[4-[[[(2S)-1-[3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]hexanoic acid;2,2,2-trifluoroacetic acid
CFAMM00380051 CHEMBL395762 Bioactive DPP-4 ligand 1
CFAMM00380021 CHEMBL184177 Bioactive (2R)-2-[4-[[[(2S)-1-[3-amino-4-[2,5-difluoro-4-(trifluoromethyl)phenyl]butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
CFAMM00380037 CHEMBL365837 Bioactive 2-[4-[[[(2S)-1-[3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
CFAMM00380020 CHEMBL366290 Bioactive (2S)-2-[4-[[[(4R)-3-[3-amino-4-(2,5-difluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
CFAMM00380036 CHEMBL184527 Bioactive (2R)-2-[4-[[[(2S)-1-[3-amino-4-(5-chloro-2-fluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
CFAMM00380026 CHEMBL1683498 Bioactive 2-[4-[[[3-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-thiazolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;hydrochloride
CFAMM00380042 CHEMBL364100 Bioactive (2S)-2-[4-[[[(2S)-1-[3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
CFAMM00380055 CHEMBL183289 Bioactive (2R)-2-[4-[[[(2S)-1-[3-amino-4-(2,3,4,5,6-pentafluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
CFAMM00380035 CHEMBL397716 Bioactive (2S)-2-[4-[[[(2S)-1-[(3R)-3-amino-4-(2,3,4,5-tetrafluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid
CFAMM00380041 CHEMBL364102 Bioactive (2R)-2-[4-[[[(2S)-1-[3-amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
CFAMM00380040 CHEMBL364103 Bioactive (2R)-2-[4-[[[(2S)-1-[3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
CFAMM00380053 CHEMBL445949 Bioactive (2S)-2-[4-[[[(2S)-1-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
CFAMM00380023 CHEMBL365010 Bioactive 2-[4-[[[(2S)-1-[3-amino-4-(2-fluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]butanoic acid;2,2,2-trifluoroacetic acid
CFAMM00380039 CHEMBL364140 Bioactive (2R)-2-[4-[[[(2S)-1-[3-amino-4-[2-fluoro-4-(trifluoromethyl)phenyl]butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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