CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7445
Family Name Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-5-[2-[4-[(dimethylamino)methyl]phenyl]ethynyl]-6-methylpyrimidin-4-amine family
No. of Seeds 6 No. of Other Members 9
Family Centroid CFAMM00152652 Functional Category Bioactive
Superfamily Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 Binder Superfamily
Class Class 2955

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Epidermal growth factor receptor and Receptor tyrosine-protein... 9 65
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Varlitinib family 2 8
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YXQ ... 2 1
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
Vascular endothelial growth factor receptor 2 and Fibroblast g... 10 3
Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... 2 12
Epidermal growth factor receptor and Mitogen-activated protein... 5 19
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 3 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 1 1
Vascular endothelial growth factor receptor 2 ligand 1-[4-[6-a... 11 13
Fatty-acid amide hydrolase 1 inhibitor (1R)-2-[[6-(3-chloro-4-... 1 4
Vascular endothelial growth factor receptor 2 ligand urea deri... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Receptor tyrosine-protein kinase erbB-2 ligand 2-[2-[4-[3-chlo... 4 5
Tyrosine-protein kinase JAK2 inhibitor N-[3-chloro-4-(4-methyl... 2 1
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 3
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 2 0
Acyl-CoA desaturase 1 inhibitor 3-[4-(2-chlorophenoxy)piperidi... 1 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 14 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 0
Glucagon receptor ligand SureCN2647807 family 3 7
Dihydrofolate reductase inhibitor 5-[[4-[2-[4-(4-aminophenyl)s... 1 0
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 4 24
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 1
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJ2 family 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 1
Glucokinase inhibitor AGN-PC-03ZE4O family 4 5


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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