CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7455
Family Name Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dichloro-1H-benzimidazol-2-yl)ethyl]-3-[4-(3-fluorophenyl)piperidin-1-yl]propanamide family
No. of Seeds 3 No. of Other Members 21
Family Centroid CFAMM00380214 Functional Category Bioactive
Superfamily Lysosomal Pro-X carboxypeptidase Binder Superfamily
Class Class 1016

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Tryptase Inhibitor Babim Family 12 90
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Platelet-activating factor receptor ligand SureCN9383514 family 4 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Lysosomal Pro-X carboxypeptidase inhibitor 2-amino-N-[(2S)-1-[... 11 16
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 0
Vascular endothelial growth factor receptor 2 and Mitogen-acti... 2 2
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... 2 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Lysosomal Pro-X carboxypeptidase inhibitor 1-[(2S)-2-(5,6-dich... 3 10
Lysosomal Pro-X carboxypeptidase inhibitor 1-[(2S)-2-(5,6-dich... 2 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 2
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
Smoothened homolog and Sonic hedgehog protein inhibitor N-cycl... 3 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 13
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 3 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-N-[(1S)-1-(... 1 0
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 4 15
Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 20 13
Lysosomal Pro-X carboxypeptidase inhibitor [4-[2-(3-chloro-4-f... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 6 6
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-[5-(6-chl... 2 0
Substance-K receptor ligand SureCN9035669 family 10 5
Coagulation factor X inhibitor SureCN1652469 family 2 1
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Lysosomal Pro-X carboxypeptidase inhibitor 1-[6-[(2S)-2-(5,6-d... 2 0
Inosine-5'-monophosphate dehydrogenase inhibitor N-(4-chloroph... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00380213 CHEMBL1950309 Bioactive N-[(1S)-1-(5,6-dichloro-1H-benzimidazol-2-yl)ethyl]-3-[4-(3-fluorophenyl)piperazin-1-yl]propanamide
CFAMM00380212 CHEMBL1684277 Bioactive 1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-(4-phenylpiperidin-1-yl)propan-1-one
CFAMM00380214 CHEMBL1950307 Bioactive N-[(1S)-1-(5,6-dichloro-1H-benzimidazol-2-yl)ethyl]-3-[4-(3-fluorophenyl)piperidin-1-yl]propanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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