CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7465
Family Name Tyrosine-protein kinase ITK/TSK inhibitor (3Z)-3-(6-methylindol-2-ylidene)-N-(1-methylpiperidin-4-yl)-1,2-dihydroindazol-5-amine family
No. of Seeds 2 No. of Other Members 40
Family Centroid CFAMM00380279 Functional Category Bioactive
Superfamily Tyrosine-protein kinase ITK/TSK and Aurora kinase A Binder Superfamily
Class Class 3190

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
Acetylcholinesterase Inhibitor 3-[2-(1-benzyl-piperidin-4-yl)-... 2 9
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
5-hydroxytryptamine receptor 6 Ligand 4-(piperazin-1-yl)-3-tos... 18 75
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 13
Serine/threonine-protein kinase Chk1 inhibitor 3-(Indol-2-yl)i... 1 1
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 2
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Transient receptor potential cation channel subfamily V member... 1 0
Aurora kinase B and Aurora kinase A inhibitor SureCN5594082 fa... 2 3
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00380279 CHEMBL1684542 Bioactive (3Z)-3-(6-methylindol-2-ylidene)-N-(1-methylpiperidin-4-yl)-1,2-dihydroindazol-5-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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