CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7483
Family Name Pol polyprotein inhibitor AC1LAHQ3 family
No. of Seeds 13 No. of Other Members 0
Family Centroid CFAMM00380639 Functional Category Bioactive
Superfamily HIV protease Inhibitor Amprenavir Superfamily
Class Class 136

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Amprenavir Family 7 15
Thymidylate synthase Inhibitor Sp-876 Family 7 117
Integrin beta-3 Inhibitor L-750034 Family 7 38
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Pol polyprotein inhibitor Lysine Sulfonamide 11o family 2 6
Pol polyprotein inhibitor Lysine Sulfonamide 14a family 12 3
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 0
Pol polyprotein and Pepsin A-5 inhibitor Lysine derivative 28 ... 2 10
Pol polyprotein inhibitor AC1LAHBI family 2 1
Kappa-type opioid receptor ligand SureCN5346063 family 4 0
Collagenase 3 inhibitor (2R)-2-[1-[(2-methylpropan-2-yl)oxycar... 4 2


External ID

Functional Category

Molecule Name

CFAMM00380650 CHEMBL2374438 Bioactive methyl N-[(2R)-1-[[(5S)-5-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-6-hydroxyhexyl]amino]-3-naphthalen-1-yl-1-oxopropan-2-yl]carbamate
CFAMM00380643 CHEMBL209023 Bioactive AC1LAHQ6
CFAMM00380649 CHEMBL2374439 Bioactive methyl N-[(2R)-1-[[(5S)-5-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-6-hydroxyhexyl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]carbamate
CFAMM00380642 CHEMBL380545 Bioactive N-[(2S)-1-[[(5S)-5-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-6-hydroxyhexyl]amino]-1-oxo-3,3-diphenylpropan-2-yl]piperazine-1-carboxamide
CFAMM00380648 CHEMBL379162 Bioactive AC1LAHRU
CFAMM00380641 CHEMBL441528 Bioactive tert-butyl N-[(2S)-1-[[(5S)-5-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-6-hydroxyhexyl]amino]-1-oxo-3,3-diphenylpropan-2-yl]carbamate
CFAMM00380647 CHEMBL207077 Bioactive AC1LAHNI
CFAMM00380640 CHEMBL378557 Bioactive AC1LAHQF
CFAMM00380646 CHEMBL168640 Bioactive PL-100
CFAMM00380639 CHEMBL208907 Bioactive AC1LAHQ3
CFAMM00380645 CHEMBL2374440 Bioactive methyl N-[(2R)-1-[[(5S)-5-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-6-hydroxyhexyl]amino]-1-oxo-3-(2-phenylphenyl)propan-2-yl]carbamate
CFAMM00380651 CHEMBL379540 Bioactive AC1LAHQI
CFAMM00380644 CHEMBL2374444 Bioactive methyl N-[(2R)-1-[[(5S)-5-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-6-hydroxyhexyl]amino]-1-oxo-3-phenylpropan-2-yl]-N-methylcarbamate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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