CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7484
Family Name Corticotropin-releasing factor receptor 1 ligand SureCN6301726 family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00380655 Functional Category Bioactive
Superfamily Adenosine receptor A3 and Adenosine receptor A1 Binder Superfamily
Class Class 3082

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Tryptase Inhibitor Babim Family 12 90
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Corticotropin-releasing factor receptor 1 ligand 3-(2-bromo-4-... 13 34
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Adenosine receptor A3 ligand 5-butyl-8-(4-methylsulfanylphenyl... 2 4
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Adenosine receptor A3 ligand SureCN6627522 family 3 2
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Adenosine receptor A3 and Adenosine receptor A1 ligand (8R)-8-... 4 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Corticotropin-releasing factor receptor 1 ligand N-butyl-N-eth... 2 1
Corticotropin-releasing factor receptor 1 ligand 3-(2,4-dibrom... 2 0
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 5 2
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[(3S)-3-[(4... 2 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 2,... 4 4
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00380655 CHEMBL168664 Bioactive SureCN6301726
CFAMM00380653 CHEMBL169979 Bioactive N-heptan-3-yl-5-methyl-3-(2,4,6-trimethylphenyl)triazolo[4,5-d]pyrimidin-7-amine
CFAMM00380652 CHEMBL169280 Bioactive 5-methyl-N-pentan-2-yl-3-(2,4,6-trimethylphenyl)triazolo[4,5-d]pyrimidin-7-amine
CFAMM00380656 CHEMBL355689 Bioactive N-heptan-4-yl-5-methyl-3-(2,4,6-trimethylphenyl)triazolo[4,5-d]pyrimidin-7-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27674 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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