CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM750
Family Name Glycogen synthase kinase-3 beta and Protein kinase C alpha type inhibitor AGN-PC-07ZA5I family
No. of Seeds 1 No. of Other Members 18
Family Centroid CFAMM00314939 Functional Category Bioactive with Natural Product
Superfamily Vascular endothelial growth factor receptor 2 and Glycogen synthase kinase-3 beta Binder Superfamily
Class Class 2498

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Indeglitazar family 3 39
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 391
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 1
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Cholinesterase and Acetylcholinesterase inhibitor 5-hydroxy-7-... 5 19
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 4 4
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand 2-... 1 26
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 1
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 6 1
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Leucyl-cystinyl aminopeptidase inhibitor SureCN988709 family 1 14
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Vascular endothelial growth factor receptor 2 ligand (4Z)-4-[(... 3 0
Mitogen-activated protein kinase 14 inhibitor Aminopyridine N-... 3 1
ATP-binding cassette sub-family G member 2 inhibitor 5-[(4-bro... 1 1
Pol polyprotein inhibitor Phenprocoumon IndolEtCONH deriv. family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00314939 CHEMBL1088149 Bioactive AGN-PC-07ZA5I

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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