CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7506
Family Name Proto-oncogene tyrosine-protein kinase Src inhibitor ethyl 2-[(2R,4R)-4-[4-amino-5-(4-hydroxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]pyrrolidin-2-yl]acetate family
No. of Seeds 4 No. of Other Members 9
Family Centroid CFAMM00380829 Functional Category Bioactive
Superfamily Proto-oncogene tyrosine-protein kinase Src and Epidermal growth factor receptor Binder Superfamily
Class Class 227

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... 9 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Adenosine kinase inhibitor 2-[[7-[(2R,3R,4S,5R)-3,4-dihydroxy-... 15 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Glucose-dependent insulinotropic receptor ligand tert-butyl 4-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00380836 CHEMBL470527 Bioactive ethyl 2-[(2S,4S)-4-[4-amino-5-(4-hydroxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]pyrrolidin-2-yl]acetate
CFAMM00380829 CHEMBL169939 Bioactive ethyl 2-[(2R,4R)-4-[4-amino-5-(4-hydroxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]pyrrolidin-2-yl]acetate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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