CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7528
Family Name Cathepsin L1 and Cathepsin K inhibitor benzyl N-[(2S)-4-methyl-1-oxo-1-[[(2S)-1-phenyl-3-(4-piperidin-1-ylanilino)propan-2-yl]amino]pentan-2-yl]carbamate family
No. of Seeds 8 No. of Other Members 22
Family Centroid CFAMM00380936 Functional Category Bioactive
Superfamily Cathepsin K and Cathepsin L1 Binder Superfamily 4
Class Class 3403

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Cyclophilin receptor and Cyclosporine receptor Ligand D-43787 ... 2 13
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Prolyl endopeptidase inhibitor benzyl (2R)-2-[(2S)-2-formylpyr... 2 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 5 2
Growth factor receptor-bound protein 2 ligand (3-aminophenyl)m... 5 13
Angiotensin-converting enzyme inhibitor (2R)-1-[4-carboxy-4-(p... 3 3
Cathepsin B and Calpain-1 catalytic subunit inhibitor AGN-PC-0... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[3-... 7 18
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-(2-anilino... 2 2
Caspase-9 and Caspase-8 inhibitor 4-fluoro-2-[[2-[[(2S)-3-meth... 1 11
Calpain-1 catalytic subunit inhibitor (4-nitrophenyl)methyl N-... 1 13
Cathepsin L1 and Cathepsin K inhibitor benzyl N-[(2R)-3-(3H-in... 1 0
Substance-P receptor ligand benzyl N-(2-amino-2-oxoethyl)-N-[2... 1 1
Sodium-dependent dopamine transporter and Sigma non-opioid int... 5 8
Matrilysin and Interstitial collagenase inhibitor [2-[(1,3-dia... 1 0
Mu-type opioid receptor and Nociceptin receptor ligand AGN-PC-... 2 7
Histone deacetylase 1 and Histone deacetylase 2 inhibitor Sure... 1 4
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 1 2
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-2-[(4-meth... 2 1


External ID

Functional Category

Molecule Name

CFAMM00380945 CHEMBL353633 Bioactive benzyl N-[(2R)-1-oxo-1-[[(2S)-4-phenyl-1-(4-piperidin-1-ylanilino)butan-2-yl]amino]propan-2-yl]carbamate
CFAMM00380930 CHEMBL172456 Bioactive benzyl N-[(2R)-4-methylsulfanyl-1-oxo-1-[[(2S)-4-phenyl-1-(4-piperidin-1-ylanilino)butan-2-yl]amino]butan-2-yl]carbamate
CFAMM00380936 CHEMBL353725 Bioactive benzyl N-[(2S)-4-methyl-1-oxo-1-[[(2S)-1-phenyl-3-(4-piperidin-1-ylanilino)propan-2-yl]amino]pentan-2-yl]carbamate
CFAMM00380946 CHEMBL171403 Bioactive benzyl N-[(2R)-3-methyl-1-oxo-1-[[(2S)-4-phenyl-1-(4-piperidin-1-ylanilino)butan-2-yl]amino]butan-2-yl]carbamate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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