CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7531
Family Name Chymase and Chymotrypsin-C inhibitor 3-[[2,2-difluoro-4-[[(2S)-1-[3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]pyrrolidine-2-carbonyl]amino]-3-oxo-5-phenylpentanoyl]amino]benzoic acid family
No. of Seeds 6 No. of Other Members 10
Family Centroid CFAMM00380973 Functional Category Bioactive
Superfamily Penicillin binding protein Inhibitor Ertapenem Superfamily
Class Class 257

Cousin Family NamesSeedsMembers
Cholecystokinin receptor type A Ligand Gi 181771 Family 3 18
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Beta-secretase 1 Inhibitor KMI-538 Family 4 20
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 5 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
Prostaglandin E2 receptor EP4 subtype ligand SureCN3567929 family 10 3
Chymase and Chymotrypsinogen A inhibitor tert-butyl N-[(2S)-1-... 2 7
Chymase and Chymotrypsinogen A inhibitor 3-[[4-[[(2S)-1-[(2S)-... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[1-[2-[4-[(2... 2 8
Beta-secretase 1 inhibitor KMI-420 family 1 6
Dipeptidyl peptidase 4 inhibitor 2-cyanopyrrolidine 24b family 1 1
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
Chymase and Chymotrypsin-C inhibitor 3-[[4-[[2-[5-amino-2-(3-m... 1 4


External ID

Functional Category

Molecule Name

CFAMM00380973 CHEMBL169707 Bioactive 3-[[2,2-difluoro-4-[[(2S)-1-[3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]pyrrolidine-2-carbonyl]amino]-3-oxo-5-phenylpentanoyl]amino]benzoic acid
CFAMM00380979 CHEMBL436061 Bioactive 3-[[4-[[(2S)-1-[4-carboxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]pyrrolidine-2-carbonyl]amino]-2,2-difluoro-3-oxo-5-phenylpentanoyl]amino]benzoic acid
CFAMM00380977 CHEMBL170879 Bioactive 4-[[2,2-difluoro-4-[[(2S)-1-[(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]pyrrolidine-2-carbonyl]amino]-3-oxo-5-phenylpentanoyl]amino]benzoic acid
CFAMM00380970 CHEMBL287318 Bioactive 3-[[2,2-difluoro-4-[[(2S)-1-[(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]pyrrolidine-2-carbonyl]amino]-3-oxo-5-phenylpentanoyl]amino]benzoic acid
CFAMM00380976 CHEMBL170838 Bioactive 3-[[4-[[(2S)-1-[(2S)-2-acetamido-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-2,2-difluoro-3-oxo-5-phenylpentanoyl]amino]benzoic acid
CFAMM00380975 CHEMBL170697 Bioactive 5-[(2S)-2-[[5-[3-(carboxymethyl)anilino]-4,4-difluoro-3,5-dioxo-1-phenylpentan-2-yl]carbamoyl]pyrrolidin-1-yl]-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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