CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM754
Family Name Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YXQ family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00314963 Functional Category Bioactive
Superfamily B-lymphocyte antigen CD20 Inhibitor Iodine-131-tositumomab Superfamily
Class Class 795

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YMN ... 7 11
Serine/threonine-protein kinase B-raf inhibitor SureCN1013580 ... 2 0
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 3 0
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Fibroblast growth factor receptor 1 and Vascular endothelial g... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Acyl-CoA desaturase 1 inhibitor 3-[4-(2-chlorophenoxy)piperidi... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 14 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-07CQG5 ... 2 1
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor AGN-PC... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00314964 CHEMBL583678 Bioactive AGN-PC-072YML
CFAMM00314963 CHEMBL1088288 Bioactive AGN-PC-072YXQ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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