CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7547
Family Name 5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine receptor 3B ligand N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-5-chloro-2,3-dihydro-1-benzofuran-7-carboxamide family
No. of Seeds 11 No. of Other Members 6
Family Centroid CFAMM00054422 Functional Category Bioactive
Superfamily Cytochrome P450 2D6 and Delta-type opioid receptor Binder Superfamily
Class Class 216

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Nemonapride Family 70 283
D(2) dopamine receptor Ligand Sulpiride Family 7 38
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Insulin receptor Ligand Meglitinides Family 9 25
C-C chemokine receptor type 2 Ligand CCX915 Family 3 25
5-hydroxytryptamine receptor 3A Ligand KB-6806 Family 12 11
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Histamine H3 receptor Ligand A-317920 Family 9 240
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Prothrombin and Tissue-type plasminogen activator inhibitor CH... 10 5
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 4 7
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
D(2) dopamine receptor ligand 2-bromo-3-chloro-N-[[(2S)-1-ethy... 1 1
D(2) dopamine receptor ligand 2-chloro-3-ethyl-N-[[(2S)-1-ethy... 3 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Prothrombin inhibitor AGN-PC-09QMX5 family 2 3
Pol polyprotein inhibitor CHEMBL305466 family 4 7
B1 bradykinin receptor ligand 4-(5-chloro-4-oxochromen-3-yl)-N... 1 5
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 1 0
C-C chemokine receptor type 1 ligand 2-[(2S)-3-(5-chlorospiro[... 2 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Dipeptidyl peptidase 4 inhibitor SureCN5777647 family 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Histone deacetylase 3 and Histone deacetylase 6 inhibitor (E)-... 1 1
Nonstructural protein 1 and Thioredoxin glutathione reductase ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00381149 CHEMBL21802 Bioactive 5-chloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,3-dihydro-1-benzofuran-7-carboxamide
CFAMM00381154 CHEMBL353993 Bioactive N-(1-azabicyclo[2.2.2]octan-3-yl)-5-chloro-3-cyclohexyl-2-methoxybenzamide
CFAMM00381147 CHEMBL353196 Bioactive 1-Acsfc
CFAMM00381153 CHEMBL170278 Bioactive AGN-PC-0041ZZ
CFAMM00381159 CHEMBL90314 Bioactive N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-5-chloro-3-iodo-2-methoxybenzamide
CFAMM00381152 CHEMBL352411 Bioactive SureCN7419706
CFAMM00381151 CHEMBL171867 Bioactive 138663-21-5
CFAMM00381157 CHEMBL424950 Bioactive N-(1-azabicyclo[2.2.2]octan-3-yl)-7-chloro-2,3,4,5-tetrahydro-1-benzoxepine-9-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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