CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7556
Family Name Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ionotropic, NMDA 2C ligand SureCN6440049 family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00381236 Functional Category Bioactive
Superfamily Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-morpholinoethyl)quinoxalin-2-amine Superfamily
Class Class 2845

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Transient receptor potential cation channel subfamily V member... 16 295
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Glucagon receptor Ligand Dwlip-gcgrrx Family 5 26
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Amg 423 family 7 47
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
GDC-0349 family 44 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Class II cytokine receptor Ligand IL-10 Family 7 45
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... 1 6
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-amin... 2 30
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Urotensin-2 receptor Ligand Palosuran Family 4 4
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
5-hydroxytryptamine receptor 3A and D(2) dopamine receptor Lig... 1 0
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 25 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YYL... 1 3
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Epidermal growth factor receptor ligand AGN-PC-076GVG family 8 1
Cathepsin K and Potassium voltage-gated channel subfamily H me... 3 1
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Survival motor neuron protein inhibitor CHEMBL1581561 family 1 3
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... 7 6
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Transient receptor potential cation channel subfamily V member... 4 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 15
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Acetylcholinesterase and Cholinesterase inhibitor 2-amino-6-[3... 1 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Transient receptor potential cation channel subfamily V member... 57 4
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Nitric oxide synthase, inducible inhibitor SureCN2258300 family 2 24
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Transient receptor potential cation channel subfamily V member... 3 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Cytochrome P450 1A2 inhibitor AGN-PC-0BTGP4 family 1 0
Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... 2 0
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00381236 CHEMBL170552 Bioactive SureCN6440049
CFAMM00381233 CHEMBL354482 Bioactive SureCN6440082

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27273 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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