CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7591
Family Name Coagulation factor X inhibitor (6S,8aS)-N-[(1-carbamimidoylpiperidin-4-yl)methyl]-2-(2,2-diphenylethylsulfonyl)-4-oxo-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide family
No. of Seeds 6 No. of Other Members 0
Family Centroid CFAMM00381507 Functional Category Bioactive
Superfamily Prothrombin and Coagulation factor X Binder Superfamily 5
Class Class 1271

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Prothrombin Inhibitor Ppack Family 5 4
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Trypsin Inhibitor P1 Argininal Derivative Family 13 36
Prolyl endopeptidase inhibitor SureCN194654 family 3 4
Coagulation factor X inhibitor (6S,8aS)-2-benzhydrylsulfonyl-N... 5 5
Plasminogen and Plasma kallikrein inhibitor CHEMBL2016864 family 9 16
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 4 2
Prothrombin and Suppressor of tumorigenicity 14 protein inhibi... 5 8
Prothrombin inhibitor SureCN7341151 family 6 7
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Prothrombin inhibitor (2S)-N-[4-(2-amino-2-iminoethyl)cyclohex... 2 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Prothrombin inhibitor ethyl (3S)-3-(benzylsulfonylamino)-1-[2-... 3 1
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 1 1
Collagenase 3 and Macrophage metalloelastase inhibitor (2R)-N-... 1 2
Cationic trypsin and Prothrombin inhibitor (3S,6S)-6-amino-6-b... 4 2
Coagulation factor X inhibitor ethyl 2-[[(3S)-3-[[2-[[(2R)-2-(... 4 0
Prothrombin inhibitor methyl (3S)-3-[[(6S,8aS)-2-benzylsulfony... 5 1
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Histamine H3 receptor ligand Conessine analogue, 13e family 1 0
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047569... 1 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00381510 CHEMBL17749 Bioactive (6S,8aS)-2-benzhydrylsulfonyl-N-[(1-carbamimidoylpiperidin-4-yl)methyl]-4-oxo-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00381509 CHEMBL17248 Bioactive (6S,8aS)-2-(2,2-diphenylethylsulfonyl)-N-[[1-[(Z)-N'-hydroxycarbamimidoyl]piperidin-4-yl]methyl]-4-oxo-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00381508 CHEMBL415990 Bioactive (6S,8aS)-N-[(4-aminocyclohexyl)methyl]-2-benzhydrylsulfonyl-4-oxo-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00381507 CHEMBL17626 Bioactive (6S,8aS)-N-[(1-carbamimidoylpiperidin-4-yl)methyl]-2-(2,2-diphenylethylsulfonyl)-4-oxo-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00381512 CHEMBL416722 Bioactive (6S,8aS)-2-benzhydrylsulfonyl-N-[[1-[(Z)-N'-hydroxycarbamimidoyl]piperidin-4-yl]methyl]-4-oxo-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00381511 CHEMBL275428 Bioactive (6S,8aS)-N-[(4-aminocyclohexyl)methyl]-2-(2,2-diphenylethylsulfonyl)-4-oxo-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27627 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543