CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7595
Family Name Coagulation factor X and Cationic trypsin inhibitor AGN-PC-0759GY family
No. of Seeds 5 No. of Other Members 13
Family Centroid CFAMM00381526 Functional Category Bioactive
Superfamily Cruzipain and Cationic trypsin Binder Superfamily
Class Class 667

Cousin Family NamesSeedsMembers
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
BIBT986 family 7 96
SB989 family 17 91
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Tryptase Inhibitor Babim Family 12 90
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Prothrombin inhibitor SureCN5856722 family 3 16
Histone deacetylase 1 and Histone deacetylase 8 inhibitor (E)-... 3 0
Histamine H4 receptor ligand SureCN602132 family 1 8
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Microsomal triglyceride transfer protein large subunit inhibit... 7 4
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 ... 6 12
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 1
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 2 4
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 1
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Fatty acid-binding protein, adipocyte inhibitor AGN-PC-02W5KO ... 2 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Type-1 angiotensin II receptor ligand AGN-PC-04X8EF family 1 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Gonadotropin-releasing hormone receptor and 5-hydroxytryptamin... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Melanin-concentrating hormone receptor 1 ligand SureCN3832854 ... 3 2
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Glutamate receptor 1 and Glutamate receptor 2 ligand 4-(1-azab... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00381529 CHEMBL366535 Bioactive methyl 3-[[3-[(7-carbamimidoylnaphthalen-2-yl)methyl]-2-methylbenzimidazol-5-yl]-(1-ethanimidoylpiperidin-4-yl)amino]-2-methylpropanoate
CFAMM00381522 CHEMBL174829 Bioactive 3-[[3-[(7-carbamimidoylnaphthalen-2-yl)methyl]-2-methylbenzimidazol-5-yl]-(1-ethanimidoylpiperidin-4-yl)amino]-2-methylpropanoic acid
CFAMM00381535 CHEMBL369480 Bioactive AGN-PC-0759GX
CFAMM00381520 CHEMBL355097 Bioactive AGN-PC-0759PO
CFAMM00381526 CHEMBL172532 Bioactive AGN-PC-0759GY

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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