CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM760
Family Name Histone deacetylase 3 and Histone deacetylase 6 inhibitor Triazole Ligand, 10c family
No. of Seeds 20 No. of Other Members 37
Family Centroid CFAMM00314994 Functional Category Bioactive
Superfamily Cathepsin S and Histone deacetylase 6 Binder Superfamily
Class Class 3219

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Sodium channel Ligand Rufinamide Family 1 3
Prothrombin Inhibitor Ximelegatran Family 8 157
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Neuromedin-K receptor Ligand SB222200 Family 17 235
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 2 14
Histone deacetylase 3 and Histone deacetylase 1 inhibitor AGN-... 2 4
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 16 10
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 5 3
Metabotropic glutamate receptor 2 ligand AGN-PC-00A1HD family 2 0
Metabotropic glutamate receptor 1 ligand GTPL6334 family 6 4
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
UDP-3-O-acyl-N-acetylglucosamine deacetylase inhibitor (2R)-N-... 5 1
Cathepsin S inhibitor N-[(S)-[1-(1-cyanocyclopropyl)triazol-4-... 5 12
Cathepsin S inhibitor N-[(S)-[1-(1-cyanocyclopropyl)triazol-4-... 1 0
Cathepsin S inhibitor 4-acetamido-N-[(S)-[1-(1-cyanocyclopropy... 4 0
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor (2... 5 5
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 0
Metabotropic glutamate receptor 1 ligand 4-[1-(2-fluoropyridin... 1 0
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Metabotropic glutamate receptor 2 ligand 8-[2-(4-fluorophenyl)... 2 3
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
KiSS-1 receptor ligand SureCN5132924 family 2 4
Metabotropic glutamate receptor 1 ligand AGN-PC-07CPMZ family 1 0
Histone deacetylase 8 and Histone deacetylase 6 inhibitor N-ox... 2 0
Prolyl endopeptidase inhibitor 1-[(2S,4S)-4-[4-(4-bromophenyl)... 1 0
Prolyl endopeptidase inhibitor 4-phenyl-1-[(2S,4S)-4-(4-pyridi... 2 1
Prolyl endopeptidase inhibitor 1-[(2S,4S)-4-(4-cyclopropyltria... 1 0
Steroid hormone receptor ERR1 ligand methyl 3-[4-(2-aminobenzo... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00315023 CHEMBL1094710 Bioactive AGN-PC-07PPIX
CFAMM00314997 CHEMBL1094709 Bioactive AGN-PC-07PPIW
CFAMM00315032 CHEMBL520056 Bioactive Triazole Ligand, 14c
CFAMM00315009 CHEMBL487741 Bioactive Triazole Ligand, 12b
CFAMM00315008 CHEMBL487742 Bioactive Triazole Ligand, 12c
CFAMM00314995 CHEMBL519746 Bioactive Triazole Ligand, 12a
CFAMM00315014 CHEMBL488747 Bioactive Triazole Ligand, 14a
CFAMM00314991 CHEMBL1091815 Bioactive AGN-PC-07PQ84
CFAMM00315030 CHEMBL1088734 Bioactive AGN-PC-07PQ83
CFAMM00314984 CHEMBL487106 Bioactive Triazole Ligand, 14b
CFAMM00315026 CHEMBL1091475 Bioactive AGN-PC-07PQ82
CFAMM00314994 CHEMBL519668 Bioactive Triazole Ligand, 10c
CFAMM00315000 CHEMBL519491 Bioactive Triazole Ligand, 6c
CFAMM00315035 CHEMBL1094707 Bioactive AGN-PC-07PPHM
CFAMM00315025 CHEMBL1091474 Bioactive AGN-PC-07PQ81
CFAMM00315041 CHEMBL483494 Bioactive Triazole Ligand, 6b
CFAMM00315004 CHEMBL487533 Bioactive Triazole Ligand, 6a
CFAMM00315034 CHEMBL483693 Bioactive Triazole Ligand, 10a
CFAMM00315011 CHEMBL483892 Bioactive Triazole Ligand, 10b
CFAMM00314998 CHEMBL1094708 Bioactive AGN-PC-07ZABK

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24536 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543