CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7601
Family Name Angiotensin-converting enzyme and Angiotensin-converting enzyme 2 inhibitor (2S)-1-[5-benzamido-4-oxo-6-(4-phenylmethoxyphenyl)hexanoyl]pyrrolidine-2-carboxylic acid family
No. of Seeds 3 No. of Other Members 13
Family Centroid CFAMM00381554 Functional Category Bioactive with Natural Product
Superfamily Sigma non-opioid intracellular receptor 1 and D(2) dopamine receptor Binder Superfamily
Class Class 2912

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Oxytocin receptor Ligand Oxytocin Family 30 182
Penicillin binding protein Inhibitor Cefadroxil Family 5 17
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Thymopentin family 20 133
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Endothelin-1 receptor Ligand Atrasentan Family 127 336
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Myeloperoxidase Inhibitor AZD5904 Family 1 2
Integrin alpha-4 Inhibitor Firategrast Family 3 93
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Tryptase Inhibitor APC-366 Family 2 12
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
Kynureninase Inhibitor 3-hydroxyhippuric Acid Family 1 9
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Integrin beta-3 Inhibitor Lamifiban Family 3 4
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
D(2) dopamine receptor Ligand Epidepride Family 31 66
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
Pol polyprotein inhibitor 180968-31-4 family 8 13
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 5 4
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 3 2
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
Endothelin B receptor and Endothelin-1 receptor ligand SureCN8... 6 4
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-7-[(4-ca... 3 14
Gamma-aminobutyric acid type B receptor subunit 1 ligand CGP-6... 3 0
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 12 0
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Prostaglandin E2 receptor EP4 subtype ligand SureCN5653729 family 3 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Mu-type opioid receptor ligand AGN-PC-075GAW family 2 1
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 0
NS3 inhibitor Proline-Based Macrocycle 24 family 6 6
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 2-... 4 2
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-d... 10 15
Metallo-beta-lactamase L1 inhibitor 3-[[1-[[(2R)-1-amino-1-oxo... 1 0
Beta-secretase 1 and Cathepsin B inhibitor N-[(2S)-1-[[(2S,3R)... 2 1
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4R)-4-(3-hydroxyp... 4 1
Caspase-1 and Caspase-8 inhibitor N-[(6S)-1-[2-[[(3S)-2-hydrox... 3 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 2 6
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)... 13 5
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 2
Pol polyprotein inhibitor AC1LA3AI family 5 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Prothrombin inhibitor (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]... 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Angiotensin-converting enzyme and Angiotensin-converting enzym... 1 0
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
N-acetylated-alpha-linked acidic dipeptidase 2 inhibitor (2S)-... 1 5
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2-chlo... 2 4
Integrin beta-3 and Integrin alpha-IIb inhibitor FRADAFIBAN fa... 1 17
Arachidonate 5-lipoxygenase inhibitor methyl 5-[1-(2-butyl-1-b... 2 4
Beta-lactamase inhibitor sodium;(1R,5S)-4-[2-amino-2-(4-hydrox... 1 0
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
Beta-secretase 1 inhibitor 3-[[[(2S)-2-[[(3S,4S)-3-hydroxy-6-m... 2 4
Dipeptidyl peptidase 4 inhibitor ethyl 2-[[4-[[4-[(2-ethoxy-2-... 7 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 0
Cathepsin K inhibitor benzyl N-[(2S)-4-methyl-1-oxo-1-[2-[[(4-... 2 0
Glutamate carboxypeptidase 2 inhibitor 2-(4-hydroxy-3-methoxyp... 1 4
Beta-lactamase inhibitor CHEMBL1316873 family 1 1
Calpain-1 catalytic subunit inhibitor (2E)-2-[(3,4-dihydroxyph... 4 0
C-C chemokine receptor type 3 ligand SureCN3932025 family 1 1
Prostaglandin D2 receptor ligand (E)-7-[(1S,3S,4R,5R)-4-[(4-hy... 1 1
72 kDa type IV collagenase and Aminopeptidase N inhibitor meth... 1 1
Prostaglandin D2 receptor ligand (E)-7-[(1S,3S,4R,5R)-4-(1,3-b... 1 0
Putative NP ZINC20611663 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00381554 CHEMBL172801 Bioactive (2S)-1-[5-benzamido-4-oxo-6-(4-phenylmethoxyphenyl)hexanoyl]pyrrolidine-2-carboxylic acid
CFAMM00381559 CHEMBL173849 Bioactive SureCN11268804
CFAMM00381552 CHEMBL173822 Bioactive (2S)-1-[5-benzamido-6-(4-hydroxyphenyl)-4-oxohexanoyl]pyrrolidine-2-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45933 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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