CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7606
Family Name Kappa-type opioid receptor and Mu-type opioid receptor ligand CHEMBL1729698 family
No. of Seeds 1 No. of Other Members 4
Family Centroid CFAMM00381594 Functional Category Bioactive
Superfamily Carbonic anhydrase 2 and Carbonic anhydrase 1 Binder Superfamily
Class Class 905

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
ATP-sensitive inward rectifier potassium channel 10 Ligand Ace... 2 64
DNA Binder Procarbazine Family 8 358
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Cathepsin K Inhibitor Odanacatib Family 33 84
C-C chemokine receptor type 5 Ligand AZD5672 Family 25 70
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Chloride channel protein 2 Ligand Acid-activated Omeprazole Fa... 1 1
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Suppressor of tumorigenicity 14 protein and Prothrombin Inhibi... 4 126
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Thymidylate synthase Inhibitor Sp-876 Family 7 117
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Integrin beta-3 Inhibitor L-750034 Family 7 38
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-pent... 4 5
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-valp... 8 5
Suppressor of tumorigenicity 14 protein Inhibitor 3-tapap Family 15 39
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... 2 7
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Trypsin Inhibitor Benzamidrazone Analogue Family 16 6
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 5
Muscarinic acetylcholine receptor M2 ligand [4-[(3R)-3-methyl-... 3 4
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Type-1 angiotensin II receptor ligand AGN-PC-04X45B family 9 12
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745OU family 6 6
B1 bradykinin receptor ligand SureCN4136698 family 6 33
Acetylcholinesterase and Butyrylcholinesterase inhibitor N-[2-... 3 7
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-044L... 6 7
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Coagulation factor X and Trypsin-1 inhibitor SureCN6161266 family 2 28
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5686807 f... 7 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-met... 8 13
Replication protein E1 inhibitor AC1LAK2U family 3 10
B1 bradykinin receptor ligand SureCN13936521 family 19 4
Kappa-type opioid receptor and Delta-type opioid receptor liga... 9 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN2769748 family 1 1
B1 bradykinin receptor ligand N-[(1R)-6-[(dimethylamino)methyl... 7 6
Cathepsin K and Cathepsin L1 inhibitor N-[1-(cyanomethylcarbam... 2 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
B1 bradykinin receptor and B2 bradykinin receptor ligand SureC... 3 0
Cannabinoid receptor 2 ligand AGN-PC-04VLWN family 9 4
Cannabinoid receptor 2 ligand N-cyclohexyl-4-propan-2-yl-3-pyr... 2 2
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 2
C-C chemokine receptor type 5 ligand N-[1-[(3R)-4-[benzenesulf... 3 1
B1 bradykinin receptor and B2 bradykinin receptor ligand SureC... 1 1
B1 bradykinin receptor ligand SureCN5950627 family 2 11
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[ethyl-[2-(4... 1 1
Motilin receptor ligand N-[[2-[4-[[(3S,5R)-3,5-dimethylpiperaz... 2 0
Cannabinoid receptor 1 ligand 1-[4-[3-cyclopropyl-5-(trifluoro... 4 1
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 5 0
Suppressor of tumorigenicity 14 protein and Prothrombin inhibi... 4 0
B1 bradykinin receptor ligand SureCN5405184 family 1 0
Lethal(3)malignant brain tumor-like protein 3 and Lethal(3)mal... 1 0
B1 bradykinin receptor ligand SureCN5392679 family 1 0
Secreted frizzled-related protein 1 and Proto-oncogene Wnt-3 i... 2 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00381596 CHEMBL221021 Bioactive AGN-PC-006WOB

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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