CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7633
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform inhibitor N-[2-chloro-5-(4-piperidin-1-ylquinolin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide family
No. of Seeds 13 No. of Other Members 1
Family Centroid CFAMM00381805 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Tyrosine-protein kinase JAK2 Binder Superfamily
Class Class 122

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Coagulation factor X Inhibitor M55113 Family 1 8
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
NF-kappa-B Inhibitor 9-chloro-5h-6-thia-4,5-diaza-chrysene 6,6... 3 27
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
5-hydroxytryptamine receptor 6 ligand AGN-PC-07ZA0N family 1 3
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Cannabinoid receptor 2 ligand 1,1,1-trifluoro-N-[(2S)-6-(1-pyr... 2 1
5-hydroxytryptamine receptor 6 ligand AGN-PC-09QKIN family 2 9
5-hydroxytryptamine receptor 2A ligand SureCN5215979 family 2 10
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 15 3
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 7 liga... 3 11
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
Glucocorticoid receptor ligand 1-[(4aS)-6-(4-tert-butylphenyl)... 27 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 6 0
Prostaglandin D2 receptor 2 ligand SureCN2516080 family 1 0
Cannabinoid receptor 1 ligand N-[[(3R,6S)-1-(4-chlorophenyl)-6... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00381809 CHEMBL1914725 Bioactive N-[2-chloro-5-(4-phenylquinolin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00381808 CHEMBL1914723 Bioactive N-[5-[4-(4-benzylpiperazin-1-yl)quinolin-6-yl]-2-chloropyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00381801 CHEMBL1914719 Bioactive N-[2-chloro-5-[4-(dimethylamino)quinolin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00381807 CHEMBL1914722 Bioactive N-[2-chloro-5-[4-(4-propan-2-ylpiperazin-1-yl)quinolin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00381800 CHEMBL1914712 Bioactive N-[2-chloro-5-(1,5-naphthyridin-2-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00381806 CHEMBL1914721 Bioactive N-[2-chloro-5-[4-(4-hydroxypiperidin-1-yl)quinolin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00381805 CHEMBL1914720 Bioactive N-[2-chloro-5-(4-piperidin-1-ylquinolin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00381804 CHEMBL1914728 Bioactive N-[2-chloro-5-[4-[4-(dimethylamino)phenyl]quinolin-6-yl]pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00381810 CHEMBL1914726 Bioactive N-[2-chloro-5-(4-pyridin-3-ylquinolin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide
CFAMM00381803 CHEMBL1914947 Bioactive N-[2-chloro-5-(3-pyridin-4-ylquinoxalin-6-yl)pyridin-3-yl]-4-fluorobenzenesulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26231 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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