CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7635
Family Name Disintegrin and metalloproteinase domain-containing protein 17 inhibitor (2R,3R)-2,3-dihydroxy-4-[(2R)-2-[2-(methylamino)-1,3-thiazol-4-yl]pyrrolidin-1-yl]-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide family
No. of Seeds 23 No. of Other Members 5
Family Centroid CFAMM00381833 Functional Category Bioactive
Superfamily Disintegrin and Cathepsin K Binder Superfamily 2
Class Class 1378

Cousin Family NamesSeedsMembers
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing... 3 16
Disintegrin and metalloproteinase domain-containing protein 17... 8 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00381834 CHEMBL1770644 Bioactive (2R,3R)-4-[(2R)-2-(2-amino-1,3-thiazol-4-yl)pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381827 CHEMBL1770649 Bioactive (2R,3R)-4-[(2R)-2-[2-(cyclopropylamino)-1,3-thiazol-4-yl]pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381839 CHEMBL1770819 Bioactive (2R,3R)-4-[(2R)-2-[5-cyano-2-(methylamino)-1,3-thiazol-4-yl]pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381817 CHEMBL1770829 Bioactive (2R,3R)-4-[(5R)-2-amino-5-[2-(ethylamino)-1,3-thiazol-4-yl]-5,7-dihydropyrrolo[3,4-d]pyrimidin-6-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381833 CHEMBL1770645 Bioactive (2R,3R)-2,3-dihydroxy-4-[(2R)-2-[2-(methylamino)-1,3-thiazol-4-yl]pyrrolidin-1-yl]-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381826 CHEMBL1770820 Bioactive (2R,3R)-2,3-dihydroxy-4-[2-methyl-2-[2-(methylamino)-1,3-thiazol-4-yl]pyrrolidin-1-yl]-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381832 CHEMBL1770646 Bioactive (2R,3R)-4-[(2R)-2-[2-(ethylamino)-1,3-thiazol-4-yl]pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381825 CHEMBL1770821 Bioactive (2R,3R)-4-[(2R,4R)-2-[2-(ethylamino)-1,3-thiazol-4-yl]-4-methylpyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381838 CHEMBL1770818 Bioactive (2R,3R)-4-[(2R)-2-[5-(4-fluorophenyl)-2-(methylamino)-1,3-thiazol-4-yl]pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381815 CHEMBL1770652 Bioactive (2R,3R)-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]-4-[(2R)-2-[2-(pyridin-3-ylamino)-1,3-thiazol-4-yl]pyrrolidin-1-yl]butanamide
CFAMM00381831 CHEMBL1770647 Bioactive (2R,3R)-2,3-dihydroxy-4-oxo-4-[(2R)-2-[2-(propylamino)-1,3-thiazol-4-yl]pyrrolidin-1-yl]-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381824 CHEMBL1770822 Bioactive (2R,3R)-4-[(2R)-4,4-difluoro-2-[2-(methylamino)-1,3-thiazol-4-yl]pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381837 CHEMBL1770817 Bioactive (2R,3R)-4-[(2R)-2-[5-cyclopropyl-2-(methylamino)-1,3-thiazol-4-yl]pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381814 CHEMBL1770651 Bioactive (2R,3R)-4-[(2R)-2-[2-(2-fluoroanilino)-1,3-thiazol-4-yl]pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381823 CHEMBL1770823 Bioactive (2R,3R)-2,3-dihydroxy-4-[(2R)-2-[2-(methylamino)-1,3-thiazol-4-yl]-2,5-dihydropyrrol-1-yl]-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381820 CHEMBL1770826 Bioactive (2R,3R)-2,3-dihydroxy-4-[(1R)-1-[2-(methylamino)-1,3-thiazol-4-yl]-1,3-dihydroisoindol-2-yl]-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381830 CHEMBL1770642 Bioactive SureCN13542822
CFAMM00381836 CHEMBL1770816 Bioactive (2R,3R)-2,3-dihydroxy-4-[(2R)-2-[5-methyl-2-(methylamino)-1,3-thiazol-4-yl]pyrrolidin-1-yl]-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381829 CHEMBL1770643 Bioactive SureCN8222906
CFAMM00381813 CHEMBL1770650 Bioactive (2R,3R)-4-[(2R)-2-[2-(cyclobutylamino)-1,3-thiazol-4-yl]pyrrolidin-1-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381822 CHEMBL1770824 Bioactive (2R,3R)-2,3-dihydroxy-4-[(1R,3R,5R)-3-[2-(methylamino)-1,3-thiazol-4-yl]-2-azabicyclo[3.1.0]hexan-2-yl]-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381835 CHEMBL1738754 Bioactive (2R,3R)-2,3-dihydroxy-4-[(2R)-2-[2-(methylamino)-5-methylsulfonyl-1,3-thiazol-4-yl]pyrrolidin-1-yl]-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide
CFAMM00381818 CHEMBL1770828 Bioactive (2R,3R)-4-[(1R)-5-fluoro-1-[2-(methylamino)-1,3-thiazol-4-yl]-1,3-dihydroisoindol-2-yl]-2,3-dihydroxy-4-oxo-N-[(1R)-1-(4-pyrazol-1-ylphenyl)ethyl]butanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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