CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7640
Family Name Mitogen-activated protein kinase 14 inhibitor 4-(2-chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-2-piperidin-4-yl-1,7-naphthyridin-7-ium family
No. of Seeds 6 No. of Other Members 7
Family Centroid CFAMM00381902 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 14 and Cannabinoid receptor 1 Binder Superfamily
Class Class 825

Cousin Family NamesSeedsMembers
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 1 4
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Sterol O-acyltransferase 1 inhibitor SureCN7073167 family 4 2
Transient receptor potential cation channel subfamily V member... 2 0
Reverse transcriptase/RNaseH inhibitor (4s)-6-chloro-4-cyclopr... 5 3


External ID

Functional Category

Molecule Name

CFAMM00381906 CHEMBL1738839 Bioactive 8-(2,6-dichlorophenyl)-4-(2,4-difluorophenyl)-7-oxido-2-piperidin-4-yl-1,7-naphthyridin-7-ium
CFAMM00381905 CHEMBL1916519 Bioactive 4-(2-chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-2-(1-propan-2-ylpiperidin-4-yl)-1,7-naphthyridin-7-ium
CFAMM00381898 CHEMBL1916520 Bioactive 2-(1-tert-butylpiperidin-4-yl)-4-(2-chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-1,7-naphthyridin-7-ium
CFAMM00381903 CHEMBL1916361 Bioactive 4-(2-chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-2-(1-methylpiperidin-4-yl)-7-oxido-1,7-naphthyridin-7-ium
CFAMM00381902 CHEMBL1916360 Bioactive 4-(2-chloro-4-fluorophenyl)-8-(2,6-dichlorophenyl)-7-oxido-2-piperidin-4-yl-1,7-naphthyridin-7-ium
CFAMM00381901 CHEMBL1916523 Bioactive 4-(2-chlorophenyl)-8-(2,6-difluorophenyl)-7-oxido-2-piperidin-4-yl-1,7-naphthyridin-7-ium

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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