CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7648
Family Name 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor ligand SureCN13533116 family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00179569 Functional Category Bioactive
Superfamily Melanin-concentrating hormone receptor 1 and D(2) dopamine receptor Binder Superfamily
Class Class 1677

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Sodium channel protein type 10 subunit alpha and Sodium channe... 1 7
D(2) dopamine receptor Ligand Aplindore Fumarate Family 2 30
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand Du 125530 Family 2 0
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Cannabinoid receptor 2 ligand 8-butoxy-N-(2-fluoro-2-phenyleth... 12 7
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 2
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Neutrophil collagenase inhibitor (3R)-2-[4-[4-(dimethylamino)p... 2 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2I family 3 3
Trace amine-associated receptor 1 ligand EPPTB family 4 9
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 5
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-(2,... 2 11
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Motilin receptor ligand SureCN14564469 family 1 6
Galanin receptor type 3 and Alpha-1A adrenergic receptor ligan... 2 16
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(1-cyanocyclop... 4 0
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 1
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 8
Poly [ADP-ribose] polymerase 1 inhibitor N-ethyl-4-[4-[(8-meth... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-0034EG family 5 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
5-hydroxytryptamine receptor 1A ligand (1R,2R)-2-[4-(2,3-dihyd... 2 3
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 4 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-(3-methoxy-2-me... 2 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Transient receptor potential cation channel subfamily V member... 2 7
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 2 0
Arachidonate 5-lipoxygenase inhibitor ethyl (E)-3-(10H-phenoxa... 1 1
Beta-lactamase and 4'-phosphopantetheinyl transferase ffp inhi... 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075HBO ... 2 44
NP (s)-3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepi... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00381949 CHEMBL69326 Bioactive SureCN6364155
CFAMM00381948 CHEMBL93421 Bioactive N-[2-[4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazin-1-yl]ethyl]cyclohexanecarboxamide
CFAMM00381952 CHEMBL316960 Bioactive AGN-PC-074VDT

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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