CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7653
Family Name 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor ligand (8R)-8-[4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)butyl-propylamino]-6,7,8,9-tetrahydro-3H-benzo[e]indole-2-carbonitrile family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00320586 Functional Category Bioactive
Superfamily Mineralocorticoid receptor and Androgen receptor Ligand WAY-255348 Superfamily
Class Class 173

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Setipiprant family 5 118
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family 9 71
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Platelet-derived growth factor receptor alpha and Platelet-der... 3 3
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Serine/threonine-protein kinase Chk1 Inhibitor BIS-IMIDE A Family 1 3
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... 2 12
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Histone deacetylase Inhibitor ST-5732 Family 8 6
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Calcitonin gene-related peptide type 1 receptor ligand CHEMBL1... 5 8
Cholecystokinin receptor type A ligand A-65186 family 2 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Pol polyprotein inhibitor N-[(2S)-1-[[(2S,3R,4S,5S)-3,4-dihydr... 2 0
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Dipeptidyl peptidase 4 inhibitor (2S)-1-[2-[5-(aminomethyl)-2-... 4 4
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Glycogen synthase kinase-3 beta and Tyrosine-protein kinase JA... 1 0
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Translocator protein inhibitor AGN-PC-08WI0V family 1 0
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Substance-K receptor ligand N-[1-[[(2S)-1-[[1-(oxan-4-ylmethyl... 3 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
ALK tyrosine kinase receptor and Insulin receptor ligand 9-eth... 9 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 4 2
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 14 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 6 6
Microsomal triglyceride transfer protein large subunit inhibit... 13 0
Cathepsin K inhibitor (1R,2R)-2-(6-chloro-1,3,4,5-tetrahydropy... 2 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... 1 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN5551829 f... 1 14
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 2 0
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Motilin receptor ligand SureCN2768052 family 3 0
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Leucine-rich repeat serine/threonine-protein kinase 2 and Vasc... 3 3
Leucine-rich repeat serine/threonine-protein kinase 2 and Plat... 1 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 8
High affinity nerve growth factor receptor ligand CHEMBL254555... 2 2
5-hydroxytryptamine receptor 5A and 5-hydroxytryptamine recept... 2 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 1 0
KiSS-1 receptor ligand SureCN5132924 family 2 4
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
C-X-C chemokine receptor type 2 and Cytochrome P450 2C9 ligand... 1 7
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Histamine H3 receptor ligand SureCN3542210 family 1 0
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Translocator protein inhibitor CHEMBL1672413 family 1 2
Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family 19 25
Endothelin-converting enzyme 1 inhibitor 5-(3,3-dimethylbutano... 1 1
Potassium voltage-gated channel subfamily A member 5 ligand 3-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00381978 CHEMBL1788324 Bioactive (8S)-8-[4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)butyl-propylamino]-6,7,8,9-tetrahydro-3H-benzo[e]indole-2-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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