CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM767
Family Name Mitogen-activated protein kinase 14 and Mast/stem cell growth factor receptor Kit ligand N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00315202 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 14 and Mast/stem cell growth factor receptor Kit Binder Superfamily
Class Class 1152

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Prothrombin Inhibitor Ximelegatran Family 8 157
Neuromedin-K receptor Ligand SB222200 Family 17 235
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Serine/threonine-protein kinase 17A and Myosin light chain kin... 3 7
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Rho-associated protein kinase 2 inhibitor 2-[(3S,4R)-4-(4-fluo... 9 0
Motilin receptor ligand SureCN2768052 family 3 0
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN4298966 f... 10 1
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Cathepsin F and Cruzipain inhibitor (2S)-N-[(1S)-1-cyano-2-phe... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00315202 CHEMBL492265 Bioactive N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide
CFAMM00315201 CHEMBL1088796 Bioactive AGN-PC-00HEQG
CFAMM00315200 CHEMBL495330 Bioactive AGN-PC-00HES5
CFAMM00315205 CHEMBL556436 Bioactive N-[(2S)-1-(cyanomethylamino)-1-oxo-3-(3-pyridazin-3-ylphenyl)propan-2-yl]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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