CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7673
Family Name Coagulation factor X and Kallikrein-1 inhibitor SureCN890858 family
No. of Seeds 5 No. of Other Members 6
Family Centroid CFAMM00382100 Functional Category Bioactive
Superfamily Kallikrein-1 and Beta-lactamase Binder Superfamily
Class Class 3305

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 16 295
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
XL-888 family 16 85
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
Nicotinamide phosphoribosyltransferase inhibitor 4-[[(7-chloro... 1 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[3-(4-chlorop... 4 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Cannabinoid receptor 2 ligand N-isoquinolin-1-yl-4-methyl-3-pi... 1 0
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Epidermal growth factor receptor ligand N-[4-(3-bromoanilino)q... 1 0
C-C chemokine receptor type 3 ligand 4-[[2-(4-chlorophenyl)eth... 2 1


External ID

Functional Category

Molecule Name

CFAMM00382096 CHEMBL177206 Bioactive SureCN890961
CFAMM00382094 CHEMBL367609 Bioactive SureCN890630
CFAMM00382100 CHEMBL174750 Bioactive SureCN890858
CFAMM00382091 CHEMBL368676 Bioactive AGN-PC-03RTCS
CFAMM00382098 CHEMBL366802 Bioactive SureCN890903

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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