CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7677
Family Name Pol polyprotein inhibitor Sulfone deriv. 31 family
No. of Seeds 15 No. of Other Members 4
Family Centroid CFAMM00382153 Functional Category Bioactive
Superfamily Renin and Pol polyprotein Binder Superfamily
Class Class 168

Cousin Family NamesSeedsMembers
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Flovagatran family 12 546
Renin Inhibitor CP-80794 Family 16 112
Neuromedin-K receptor Ligand Senktide Family 15 22
Cruzipain Inhibitor WRR-204 Family 18 35
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Cathepsin B and Cathepsin S Inhibitor Cbz-ile-leu-ala-leuvsme ... 12 14
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Protein farnesyltransferase subunit beta Inhibitor L-739750 Fa... 4 0
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Pol polyprotein inhibitor 169168-45-0 family 7 11
Pol polyprotein inhibitor 169273-51-2 family 10 0
Pol polyprotein inhibitor AC1LA3TO family 8 0
Renin inhibitor (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[... 12 1
Renin inhibitor (2S,4S,5S)-N-(4-aminobutyl)-6-cyclohexyl-4-hyd... 32 2
Pol polyprotein inhibitor penicillin deriv. 49 family 3 19
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Pol polyprotein inhibitor penicillin deriv. 69 family 1 1
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Renin and Cathepsin D inhibitor (2S)-N-[(2S,3R,4S)-1-cyclohexy... 13 2
Renin inhibitor tert-butyl N-[1-[[(3S,6S,7R)-6-(cyclohexylmeth... 14 1
Pol polyprotein inhibitor benzyl N-[(2S,3R)-4-[(3aR,6S,7aS)-6-... 3 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-cycl... 1 6
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 16 1
Pol polyprotein inhibitor AC1LADQG family 7 1
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 3 3
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 11
Beta-secretase 1 and Cathepsin B inhibitor SureCN4666465 family 9 4
Cathepsin E and Renin inhibitor (2S)-N-[2-[[(2S,3S,5S)-1-cyclo... 4 0
Beta-secretase 1 and Cathepsin B inhibitor 3-chloro-N-[(2S)-1-... 2 0
Renin inhibitor (1R,2R,3S)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl... 5 0
Pol polyprotein inhibitor AC1LAH8S family 11 1
Pol polyprotein inhibitor [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydr... 4 15
Pol polyprotein inhibitor AC1L9R8I family 1 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3R)-1-cyclohexyl-3-h... 2 0
Pol polyprotein inhibitor AC1LA3V9 family 2 1
Pol polyprotein inhibitor AC1LACBC family 2 0
Pol polyprotein inhibitor AC1LAH9D family 1 0
Pol polyprotein and Pepsin A inhibitor cgp 53820 family 1 1
Renin inhibitor MRM-HFA-CYM-CPY family 1 0
Pol polyprotein inhibitor (2R,4S)-N-[(2S)-3-[(3S,4aS,8aS)-3-(t... 1 0
Pol polyprotein inhibitor AC1LA6OP family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00382148 CHEMBL277801 Bioactive 147977-19-3
CFAMM00382141 CHEMBL327194 Bioactive AC1LA4LO
CFAMM00382154 CHEMBL261340 Bioactive 147949-29-9
CFAMM00382147 CHEMBL321778 Bioactive 174173-74-1
CFAMM00382153 CHEMBL17494 Bioactive Sulfone deriv. 31
CFAMM00382146 CHEMBL17600 Bioactive [(2S,3S)-2-ethyl-1,1-dioxothiolan-3-yl] N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate
CFAMM00382151 CHEMBL328233 Bioactive AC1LA4MO
CFAMM00382144 CHEMBL316718 Bioactive 174173-75-2
CFAMM00382157 CHEMBL91610 Bioactive AC1LA4MR
CFAMM00382150 CHEMBL278416 Bioactive sulfone deriv. 34
CFAMM00382143 CHEMBL414648 Bioactive [(2R,3R)-2-propan-2-ylthiolan-3-yl] N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate
CFAMM00382149 CHEMBL17788 Bioactive sulfone deriv. 33
CFAMM00382142 CHEMBL90313 Bioactive AC1LA4M6
CFAMM00382155 CHEMBL330565 Bioactive AC1LA4MU

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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