CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7679
Family Name 5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6-methoxy-1,2,3,4-tetrahydrocarbazol-4-yl]-N,N-dimethylmethanamine family
No. of Seeds 11 No. of Other Members 2
Family Centroid CFAMM00382167 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 Binder Superfamily 3
Class Class 44

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Serine/threonine-protein kinase PLK1 Inhibitor HMN-214 Family 3 58
Apricoxib family 8 77
Indeglitazar family 3 39
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methyls... 3 12
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 6
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
5-hydroxytryptamine receptor 6 ligand N-[3-[[(2R)-1-methylpyrr... 6 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Cannabinoid receptor 2 ligand AGN-PC-09M5M9 family 1 0
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 15
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Coagulation factor X and Anionic trypsin-2 inhibitor AGN-PC-07... 1 1
Progesterone receptor and Androgen receptor ligand AGN-PC-04QD... 1 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Arachidonate 15-lipoxygenase inhibitor AGN-PC-075CKO family 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
5-hydroxytryptamine receptor 6 ligand CHEMBL1950763 family 1 1
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
5-hydroxytryptamine receptor 6 ligand SureCN5253197 family 4 2
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
5-hydroxytryptamine receptor 6 ligand 9-(4-methoxyphenyl)sulfo... 1 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
5-hydroxytryptamine receptor 6 ligand 1-(2-bromo-4-methoxyphen... 2 1
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 3 3
Oxytocin receptor and Vasopressin V1a receptor ligand 4-methox... 9 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-(1-methyl-4... 14 12
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 1 0
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 14 2
Carbonic anhydrase 2 inhibitor (2-sulfamoyl-1H-indol-6-yl) ace... 2 0
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Corticotropin-releasing factor receptor 1 ligand 2-[2,6-dimeth... 10 10
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 4
Carbonic anhydrase 2 inhibitor 6-hydroxy-1H-indole-2-sulfonami... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00382163 CHEMBL2165557 Bioactive 6-methoxy-N,N-dimethyl-9-(4-methylphenyl)sulfonyl-1,2,3,4-tetrahydrocarbazol-3-amine
CFAMM00382170 CHEMBL178691 Bioactive AGN-PC-075AHI
CFAMM00382176 CHEMBL365040 Bioactive SureCN5762662
CFAMM00382175 CHEMBL175068 Bioactive AGN-PC-075AO1
CFAMM00382174 CHEMBL177107 Bioactive AGN-PC-075AQE
CFAMM00382167 CHEMBL92093 Bioactive 1-[9-(benzenesulfonyl)-6-methoxy-1,2,3,4-tetrahydrocarbazol-4-yl]-N,N-dimethylmethanamine
CFAMM00382173 CHEMBL2165548 Bioactive 9-(2-bromophenyl)sulfonyl-6-methoxy-N,N-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine
CFAMM00382166 CHEMBL2165527 Bioactive 9-(benzenesulfonyl)-6-methoxy-N,N-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine
CFAMM00382172 CHEMBL2165544 Bioactive 6-methoxy-N,N-dimethyl-9-[3-(trifluoromethyl)phenyl]sulfonyl-1,2,3,4-tetrahydrocarbazol-3-amine
CFAMM00382164 CHEMBL2165552 Bioactive 9-(2-fluorophenyl)sulfonyl-6-methoxy-N,N-dimethyl-1,2,3,4-tetrahydrocarbazol-3-amine
CFAMM00382171 CHEMBL366935 Bioactive AGN-PC-075AWH

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27272 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543