CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM768
Family Name Prostaglandin E2 receptor EP3 subtype ligand (E)-3-[1-(naphthalen-2-ylmethyl)-2-oxo-3H-indol-7-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamide family
No. of Seeds 13 No. of Other Members 5
Family Centroid CFAMM00315207 Functional Category Bioactive
Superfamily Nuclear receptor ROR-gamma and Prostaglandin E2 receptor EP3 subtype Binder Superfamily
Class Class 3220

Cousin Family NamesSeedsMembers
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor N-(4-s... 12 92
Potassium voltage-gated channel subfamily A member 5 Ligand N-... 8 32
C-C chemokine receptor type 8 Ligand N-(4-phenylsulfamoyl-naph... 4 62
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-[1-[(2,4-di... 20 3
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(4,5-dichlo... 4 9
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-dichlo... 8 0
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-[1-[(2,4-di... 8 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 3 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 7 1
Prostaglandin E2 receptor EP1 subtype and Prostaglandin D2 rec... 1 4
Prostaglandin E2 receptor EP3 subtype and Prostaglandin F2-alp... 7 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin F2-alp... 5 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00315211 CHEMBL1091145 Bioactive (E)-3-[1-[(3,4-difluorophenyl)methyl]-2-oxo-3H-indol-7-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamide
CFAMM00315225 CHEMBL1093843 Bioactive (E)-3-[3,3-difluoro-1-(naphthalen-2-ylmethyl)-2-oxoindol-7-yl]-N-(3,4-difluorophenyl)sulfonylprop-2-enamide
CFAMM00315210 CHEMBL1090460 Bioactive (E)-3-[3-methyl-1-(naphthalen-2-ylmethyl)-2-oxo-3H-indol-7-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamide
CFAMM00315224 CHEMBL1091621 Bioactive (E)-3-[1-[(3,4-difluorophenyl)methyl]-3,3-difluoro-2-oxoindol-7-yl]-N-(3,4-difluorophenyl)sulfonylprop-2-enamide
CFAMM00315216 CHEMBL1093559 Bioactive (E)-3-[3,3-difluoro-1-(naphthalen-2-ylmethyl)-2-oxoindol-7-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamide
CFAMM00315223 CHEMBL1090455 Bioactive (E)-N-(4-fluorophenyl)sulfonyl-3-[1-(naphthalen-2-ylmethyl)-2,3-dioxoindol-7-yl]prop-2-enamide
CFAMM00315215 CHEMBL1090888 Bioactive (E)-3-[3,3-difluoro-1-(naphthalen-2-ylmethyl)-2-oxoindol-7-yl]-N-(4-fluorophenyl)sulfonylprop-2-enamide
CFAMM00315207 CHEMBL1088815 Bioactive (E)-3-[1-(naphthalen-2-ylmethyl)-2-oxo-3H-indol-7-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamide
CFAMM00315214 CHEMBL1088822 Bioactive (E)-N-(3,4-difluorophenyl)sulfonyl-3-[1-(naphthalen-2-ylmethyl)-2-oxo-3H-indol-7-yl]prop-2-enamide
CFAMM00315221 CHEMBL1090459 Bioactive (E)-N-(3,4-difluorophenyl)sulfonyl-3-[3-methyl-1-(naphthalen-2-ylmethyl)-2-oxo-3H-indol-7-yl]prop-2-enamide
CFAMM00315220 CHEMBL1093790 Bioactive (E)-3-[1-(naphthalen-2-ylmethyl)-2,3-dioxoindol-7-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamide
CFAMM00315226 CHEMBL479868 Bioactive (E)-3-[1-[(3,4-difluorophenyl)methyl]-3-methyl-2-oxo-3H-indol-7-yl]-N-(2,4,5-trifluorophenyl)sulfonylprop-2-enamide
CFAMM00315218 CHEMBL1088847 Bioactive (E)-3-[1-[(3,4-difluorophenyl)methyl]-2-oxo-3H-indol-7-yl]-N-(3,4-difluorophenyl)sulfonylprop-2-enamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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