CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7688
Family Name Prothrombin and Trypsin-1 inhibitor 1-[2-(4-benzylpiperidin-1-yl)-2-oxoethyl]-3-(2-hydroxyethyl)indole-5-carboximidamide family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00382258 Functional Category Bioactive
Superfamily Caspase-1 and Trypsin-1 Binder Superfamily
Class Class 1127

Cousin Family NamesSeedsMembers
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Substance-P receptor Ligand GSK424887 Family 8 184
Coagulation factor X Inhibitor Otamixaban Family 9 21
Growth hormone receptor Ligand EP-51216 Family 34 390
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Endothelin B receptor Ligand IRL-2500 Family 34 87
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
NS5B protein inhibitor AC1NQMYG family 6 12
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 10 9
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 20 37
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 5 2
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[2-(1H-ind... 1 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00382255 CHEMBL422722 Bioactive methyl 2-[1-[2-(4-benzylpiperidin-1-yl)-2-oxoethyl]-5-carbamimidoylindol-3-yl]acetate
CFAMM00382258 CHEMBL175398 Bioactive 1-[2-(4-benzylpiperidin-1-yl)-2-oxoethyl]-3-(2-hydroxyethyl)indole-5-carboximidamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27260 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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