CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM7692
Family Name D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E)-4-[4-(2,3-dichlorophenyl)piperazin-1-yl]but-2-enyl]benzamide family
No. of Seeds 24 No. of Other Members 11
Family Centroid CFAMM00176357 Functional Category Bioactive
Superfamily D(3) dopamine receptor and D(2) dopamine receptor Binder Superfamily 4
Class Class 1375

Cousin Family NamesSeedsMembers
Glycine receptor subunit beta Ligand Gw 468816 Family 4 67
Kinesin-like protein KIF11 Inhibitor Ispinesib Family 4 37
Motilin receptor Ligand GSK962040 Family 30 457
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 19 186
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Peroxisome proliferator-activated receptor gamma and Retinoic ... 4 9
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(2,4... 3 6
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
MO15-related protein kinase Pfmrk Inhibitor 2-chloro-n-(o-toly... 6 28
D(2) dopamine receptor Ligand PD-168077 Family 6 5
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Substance-K receptor and Substance-P receptor ligand N-[4-[[4-... 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 15 24
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
Lethal factor inhibitor (2R)-6-[(4-chlorophenyl)methylamino]-2... 3 0
Neuropeptide Y receptor type 2 ligand N-[3-chloro-4-[2-(cyclop... 1 2
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-5-amino-2-c... 3 4
Vasopressin V2 receptor ligand [2-chloro-4-(prop-2-enylamino)p... 3 14
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Cellular tumor antigen p53 and Inositol monophosphatase 1 inhi... 1 12
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
Equilibrative nucleoside transporter 1 inhibitor Draflazine fa... 1 8
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 7 4
Ghrelin/growth hormone secretagogue receptor ligand AGN-PC-00A... 7 27
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 2 2
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 2
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-(2-... 1 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor AGN-PC-050YNC family 1 6
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-050YWL family 2 4
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
P2X purinoceptor 7 inhibitor SureCN3659568 family 3 0
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
Coagulation factor X and Prothrombin inhibitor SureCN14502287 ... 16 5
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Histamine H3 receptor ligand AGN-PC-0CW63F family 1 1
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 3
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
Kappa-type opioid receptor and Urotensin-2 receptor ligand 2-(... 5 1
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
Substance-K receptor and Neuromedin-K receptor ligand SureCN78... 2 4
Muscarinic acetylcholine receptor M1 and Beta-lactamase ligand... 1 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 14 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
Substance-P receptor and Substance-K receptor ligand 2-[3-[1-[... 10 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[5-... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 7 5
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Mitogen-activated protein kinase 14 inhibitor 5-(2-chloro-4-fl... 3 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Urotensin-2 receptor and Kappa-type opioid receptor ligand Sur... 2 0
Somatostatin receptor type 1 ligand AGN-PC-078XL4 family 2 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 4
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Cannabinoid receptor 1 ligand SureCN14463736 family 2 0
C-C chemokine receptor type 5 ligand AC1MHP8Y family 1 0
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 4 6
Inositol monophosphatase 1 and Retinal dehydrogenase 1 inhibit... 1 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 3
P2X purinoceptor 7 inhibitor SureCN3720401 family 1 0
Transient receptor potential M8 protein ligand 1-[(2S)-2-(2-ch... 4 2
C-C chemokine receptor type 2 ligand AGN-PC-00D2HV family 2 2
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 1 5
Glutamate receptor 1 and Glutamate receptor 2 ligand SureCN621... 1 3
Tubulin beta-2B chain and Similar to alpha-tubulin isoform 1 i... 1 0
E3 ubiquitin-protein ligase Mdm2 inhibitor SureCN5171589 family 10 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00382273 CHEMBL430439 Bioactive AGN-PC-074KG2
CFAMM00382264 CHEMBL175677 Bioactive N-[(E)-4-[4-(2,3-dichlorophenyl)piperazin-1-yl]but-2-enyl]-3-fluorobenzamide
CFAMM00382266 CHEMBL366900 Bioactive N-[(E)-4-[4-(2,3-dichlorophenyl)piperazin-1-yl]but-2-enyl]-4-fluorobenzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26825 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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